Detailed information of TA system TA154055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 49711..50212
• Replicon: plasmid p20723-3
• Accession: NZ_CP051424
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain CVM 20723

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: Q9F571
• Locus tag: HFQ25_RS00905
• Protein ID: WP_000702246.1
• Coordinates: 49952..50212 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: HFQ25_RS00900
• Protein ID: WP_001132407.1
• Coordinates: 49711..49962 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFQ25_RS00860	44906..45607	+	702	WP_000280995.1	hypothetical protein	-
HFQ25_RS00865	45654..46253	+	600	WP_000091422.1	hypothetical protein	-
HFQ25_RS00870	46273..46599	+	327	WP_000206697.1	hypothetical protein	-
HFQ25_RS00875	46730..47167	-	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
HFQ25_RS00880	47192..47374	-	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
HFQ25_RS00885	47908..48090	+	183	WP_001481829.1	hypothetical protein	-
HFQ25_RS00890	48197..48463	-	267	WP_000681608.1	type II toxin-antitoxin system HicB family antitoxin	-
HFQ25_RS00895	48883..49161	-	279	WP_000545937.1	hypothetical protein	-
HFQ25_RS00900	49711..49962	-	252	WP_001132407.1	transcriptional regulator	Antitoxin
HFQ25_RS00905	49952..50212	-	261	WP_000702246.1	hypothetical protein	Toxin
HFQ25_RS00910	50263..50487	-	225	WP_000814384.1	hypothetical protein	-
HFQ25_RS00915	50585..50794	-	210	WP_000866037.1	hypothetical protein	-
HFQ25_RS00920	50836..51159	-	324	WP_000427402.1	hypothetical protein	-
HFQ25_RS00925	51740..52069	-	330	WP_000855118.1	hypothetical protein	-
HFQ25_RS00930	52667..53332	+	666	WP_000532148.1	P-loop NTPase	-
HFQ25_RS00935	53411..53695	+	285	WP_001162371.1	hypothetical protein	-
HFQ25_RS00940	53713..54309	-	597	WP_000125165.1	hypothetical protein	-
HFQ25_RS00945	54459..54620	-	162	WP_001366886.1	type I toxin-antitoxin system Hok family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..57420	57420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 12822.38 Da
• Isoelectric Point: 5.5500

>T154055 WP_000702246.1 NZ_CP051424:c50212-49952 [Salmonella enterica subsp. enterica serovar Uganda]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFF

Nucleotide

• Length: 261 bp

>T154055 NZ_CP067307:2307641-2307817 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGTCAGCAACCATTTGAAACTTGG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT154055 WP_001132407.1 NZ_CP051424:c49962-49711 [Salmonella enterica subsp. enterica serovar Uganda]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT154055 NZ_CP067307:2307863-2308279 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCATTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Structures

Toxin

• AlphaFold DB: A0A3E1XBA7