Detailed information of TA system TA154054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 52440..52999
• Replicon: plasmid p20723-2
• Accession: NZ_CP051420
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain CVM 20723

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YB49
• Locus tag: HFQ25_RS00355
• Protein ID: WP_000421259.1
• Coordinates: 52440..52715 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: HFQ25_RS00360
• Protein ID: WP_001178087.1
• Coordinates: 52715..52999 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFQ25_RS00320	48158..48412	+	255	WP_000343106.1	hypothetical protein	-
HFQ25_RS00325	48412..49002	+	591	WP_053289960.1	hypothetical protein	-
HFQ25_RS00330	49215..50267	+	1053	WP_000655519.1	hypothetical protein	-
HFQ25_RS00335	50443..51045	+	603	WP_000521606.1	hypothetical protein	-
HFQ25_RS00340	51101..51595	+	495	WP_015058884.1	hypothetical protein	-
HFQ25_RS00345	51595..51861	+	267	WP_000627832.1	hypothetical protein	-
HFQ25_RS00350	52053..52334	-	282	WP_001105066.1	hypothetical protein	-
HFQ25_RS00355	52440..52715	-	276	WP_000421259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFQ25_RS00360	52715..52999	-	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
HFQ25_RS00365	53903..54934	-	1032	WP_000907852.1	replication initiation protein	-
HFQ25_RS00370	55907..56170	+	264	WP_001324596.1	ash family protein	-
HFQ25_RS00375	56088..56375	+	288	WP_000074849.1	conjugal transfer protein TraA	-
HFQ25_RS00380	56817..57350	+	534	WP_001372168.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83778	83778

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 13558.26 Da
• Isoelectric Point: 5.5500

>T154054 WP_000421259.1 NZ_CP051420:c52715-52440 [Salmonella enterica subsp. enterica serovar Uganda]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Nucleotide

• Length: 276 bp

>T154054 NZ_CP067307:c2185865-2185671 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 13999.79 Da
• Isoelectric Point: 5.5500

>AT154054 WP_001178087.1 NZ_CP051420:c52999-52715 [Salmonella enterica subsp. enterica serovar Uganda]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Nucleotide

• Length: 285 bp

>AT154054 NZ_CP067307:2185494-2185672 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: U9YB49

Antitoxin

• AlphaFold DB: U9Y625