Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 6750..7297 Replicon plasmid p20760-1
Accession NZ_CP051411
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain CVM 20760

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag HFQ56_RS22915 Protein ID WP_000969996.1
Coordinates 7016..7297 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HFQ56_RS22910 Protein ID WP_000079941.1
Coordinates 6750..7019 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFQ56_RS22890 2394..2927 - 534 WP_001303319.1 transcription termination factor NusG -
HFQ56_RS22895 3369..3656 - 288 WP_000074849.1 conjugal transfer protein TraA -
HFQ56_RS22900 3574..3837 - 264 WP_001324596.1 ash family protein -
HFQ56_RS22905 4810..5841 + 1032 WP_000907875.1 replication initiation protein -
HFQ56_RS22910 6750..7019 + 270 WP_000079941.1 hypothetical protein Antitoxin
HFQ56_RS22915 7016..7297 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFQ56_RS22920 7337..8185 + 849 WP_001057996.1 3'-5' exonuclease -
HFQ56_RS22925 8422..8580 - 159 WP_197711125.1 MerR family transcriptional regulator -
HFQ56_RS22930 8542..9156 + 615 Protein_12 helix-turn-helix domain-containing protein -
HFQ56_RS22935 9165..10025 + 861 WP_000493383.1 EamA family transporter -
HFQ56_RS22940 10057..11256 - 1200 WP_000804064.1 tetracycline efflux MFS transporter Tet(A) -
HFQ56_RS22945 11362..12012 + 651 WP_000164043.1 tetracycline resistance transcriptional repressor TetR(A) -
HFQ56_RS22950 12044..12286 - 243 WP_000844627.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125574 125574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T154053 WP_000969996.1 NZ_CP051411:7016-7297 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T154053 NZ_CP067307:c2036272-2036165 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGAGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT154053 WP_000079941.1 NZ_CP051411:6750-7019 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT154053 NZ_CP067307:2036319-2036385 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References