Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 65099..65624 Replicon plasmid p20762-2
Accession NZ_CP051406
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 20762

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag HFQ58_RS24180 Protein ID WP_001159863.1
Coordinates 65319..65624 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag HFQ58_RS24175 Protein ID WP_000813641.1
Coordinates 65099..65317 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFQ58_RS24150 60386..60767 + 382 Protein_72 YgiW/YdeI family stress tolerance OB fold protein -
HFQ58_RS24155 60936..61380 + 445 Protein_73 site-specific integrase -
HFQ58_RS24160 61639..62628 - 990 WP_001527061.1 RepB family plasmid replication initiator protein -
HFQ58_RS24165 63122..63418 - 297 WP_001687482.1 hypothetical protein -
HFQ58_RS24170 63902..64423 - 522 WP_010999942.1 hypothetical protein -
HFQ58_RS24175 65099..65317 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HFQ58_RS24180 65319..65624 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
HFQ58_RS24185 65626..65916 + 291 WP_001266176.1 hypothetical protein -
HFQ58_RS24190 65913..66434 + 522 WP_000198608.1 hypothetical protein -
HFQ58_RS24195 66469..67251 + 783 WP_000082169.1 site-specific integrase -
HFQ58_RS24200 67260..67973 + 714 Protein_82 EAL domain-containing protein -
HFQ58_RS24205 67977..68486 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
HFQ58_RS24210 68480..68965 + 486 WP_000905606.1 membrane protein -
HFQ58_RS24215 69242..69529 - 288 WP_071530243.1 hypothetical protein -
HFQ58_RS24220 69685..70245 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95919 95919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T154052 WP_001159863.1 NZ_CP051406:65319-65624 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T154052 NZ_CP067307:c2035736-2035629 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT154052 WP_000813641.1 NZ_CP051406:65099-65317 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT154052 NZ_CP067307:2035789-2035850 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References