Detailed information of TA system TA154051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 35549..36174
• Replicon: plasmid p20762-2
• Accession: NZ_CP051406
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 20762

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HFQ58_RS24005
• Protein ID: WP_000911322.1
• Coordinates: 35549..35947 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HFQ58_RS24010
• Protein ID: WP_000450265.1
• Coordinates: 35947..36174 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFQ58_RS23990	31740..32234	+	495	WP_010999946.1	entry exclusion protein	-
HFQ58_RS23995	32270..33001	+	732	WP_000782438.1	complement resistance protein TraT	-
HFQ58_RS24000	33378..35540	+	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
HFQ58_RS24005	35549..35947	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HFQ58_RS24010	35947..36174	-	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..95919	95919

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T154051 WP_000911322.1 NZ_CP051406:c35947-35549 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T154051 NZ_CP067307:1868124-1868501 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGTATCGCGCTGCCCGTCTCCCGTAACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
GGCGCCTGTACCTGTTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT154051 WP_000450265.1 NZ_CP051406:c36174-35947 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT154051 NZ_CP067307:1867666-1868034 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCTTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA