Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 69003..69550 Replicon plasmid p20762-1
Accession NZ_CP051405
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 20762

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag HFQ58_RS23585 Protein ID WP_000970007.1
Coordinates 69269..69550 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HFQ58_RS23580 Protein ID WP_000079941.1
Coordinates 69003..69272 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFQ58_RS23560 64647..65180 - 534 WP_001303319.1 transcription termination factor NusG -
HFQ58_RS23565 65622..65909 - 288 WP_000074849.1 conjugal transfer protein TraA -
HFQ58_RS23570 65827..66090 - 264 WP_001324596.1 ash family protein -
HFQ58_RS23575 67063..68094 + 1032 WP_000907873.1 replication initiation protein -
HFQ58_RS23580 69003..69272 + 270 WP_000079941.1 hypothetical protein Antitoxin
HFQ58_RS23585 69269..69550 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFQ58_RS23590 69590..70438 + 849 WP_001057991.1 3'-5' exonuclease -
HFQ58_RS23595 70555..71028 + 474 WP_001334658.1 hypothetical protein -
HFQ58_RS23600 71505..71771 - 267 WP_000955263.1 hypothetical protein -
HFQ58_RS23605 71771..72265 - 495 WP_001459505.1 hypothetical protein -
HFQ58_RS23610 72321..72923 - 603 WP_000517695.1 hypothetical protein -
HFQ58_RS23615 73277..74161 + 885 Protein_77 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99003 99003


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T154049 WP_000970007.1 NZ_CP051405:69269-69550 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T154049 NZ_CP067307:c1172467-1172249 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT154049 WP_000079941.1 NZ_CP051405:69003-69272 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT154049 NZ_CP067307:c1172867-1172493 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References