Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 91390..93013 Replicon plasmid p22437-1
Accession NZ_CP051397
Organism Salmonella enterica subsp. enterica serovar Uganda strain CVM 22437

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag HFQ89_RS24015 Protein ID WP_000088044.1
Coordinates 91688..93013 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6M3PBR7
Locus tag HFQ89_RS24010 Protein ID WP_012477377.1
Coordinates 91390..91683 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFQ89_RS24000 86639..89623 + 2985 WP_021242989.1 Tn3 family transposase -
HFQ89_RS24005 89702..90706 + 1005 WP_000427623.1 IS110-like element IS4321 family transposase -
HFQ89_RS24010 91390..91683 + 294 WP_012477377.1 helix-turn-helix transcriptional regulator Antitoxin
HFQ89_RS24015 91688..93013 + 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
HFQ89_RS24020 93074..93280 + 207 WP_000134171.1 hypothetical protein -
HFQ89_RS24025 93381..93791 + 411 WP_000985909.1 hypothetical protein -
HFQ89_RS24030 93804..94619 + 816 WP_001641519.1 HNH endonuclease -
HFQ89_RS24035 94872..95297 + 426 WP_000278471.1 hypothetical protein -
HFQ89_RS24040 95846..96154 + 309 WP_001224686.1 hypothetical protein -
HFQ89_RS24045 96170..96391 + 222 Protein_100 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..191208 191208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T154044 WP_000088044.1 NZ_CP051397:91688-93013 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T154044 NZ_CP067307:286628-286801 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT154044 WP_012477377.1 NZ_CP051397:91390-91683 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT154044 NZ_CP067307:286304-286600 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3PBR7

References