Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 68272..68915 Replicon plasmid p24350-2
Accession NZ_CP051388
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 24350

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag HFR97_RS24665 Protein ID WP_001034044.1
Coordinates 68272..68688 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag HFR97_RS24670 Protein ID WP_001261286.1
Coordinates 68685..68915 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFR97_RS24645 63412..64634 + 1223 WP_165419135.1 IS3-like element IS2 family transposase -
HFR97_RS24650 64685..65371 + 687 Protein_67 IS1 family transposase -
HFR97_RS24655 65625..66647 - 1023 WP_000361402.1 helicase UvrD -
HFR97_RS24660 66632..68197 - 1566 WP_001128474.1 AAA family ATPase -
HFR97_RS24665 68272..68688 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
HFR97_RS24670 68685..68915 - 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HFR97_RS24675 69543..69761 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
HFR97_RS24680 69763..70068 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
HFR97_RS24685 70069..70875 + 807 WP_000016970.1 site-specific integrase -
HFR97_RS24690 71597..72352 + 756 WP_000852146.1 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120420 120420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T154041 WP_001034044.1 NZ_CP051388:c68688-68272 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T154041 NZ_CP067303:c4191806-4191699 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT154041 WP_001261286.1 NZ_CP051388:c68915-68685 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT154041 NZ_CP067303:4191854-4191920 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References