Detailed information of TA system TA154036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 8526..10149
• Replicon: plasmid p24359-1
• Accession: NZ_CP051382
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain CVM 24359

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: H9TH67
• Locus tag: HFS04_RS23290
• Protein ID: WP_000088046.1
• Coordinates: 8824..10149 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A5Z6V2D1
• Locus tag: HFS04_RS23285
• Protein ID: WP_024136327.1
• Coordinates: 8526..8819 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS04_RS23260	4398..5639	+	1242	WP_001053338.1	VWA domain-containing protein	-
HFS04_RS23265	6202..6483	-	282	WP_000077926.1	hypothetical protein	-
HFS04_RS23270	6533..6724	-	192	WP_000398480.1	hypothetical protein	-
HFS04_RS23275	6816..7157	-	342	WP_001151575.1	hypothetical protein	-
HFS04_RS23280	7530..7922	+	393	WP_000341066.1	hypothetical protein	-
HFS04_RS23285	8526..8819	+	294	WP_024136327.1	helix-turn-helix transcriptional regulator	Antitoxin
HFS04_RS23290	8824..10149	+	1326	WP_000088046.1	type II toxin-antitoxin system HipA family toxin	Toxin
HFS04_RS23295	10210..10416	+	207	WP_000134171.1	hypothetical protein	-
HFS04_RS23300	10518..10928	+	411	WP_000985911.1	hypothetical protein	-
HFS04_RS23305	10941..11756	+	816	WP_001572439.1	HNH endonuclease	-
HFS04_RS23310	12010..12435	+	426	WP_001043843.1	hypothetical protein	-
HFS04_RS23315	13047..13751	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..235025	235025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 56670.97 Da
• Isoelectric Point: 13.4444

>T154036 WP_000088046.1 NZ_CP051382:8824-10149 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 1326 bp

>T154036 NZ_CP067303:c3427353-3427018 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 12579.08 Da
• Isoelectric Point: 12.7867

>AT154036 WP_024136327.1 NZ_CP051382:8526-8819 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 294 bp

>AT154036 NZ_CP067303:c3427601-3427353 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A3T0VBU1

Antitoxin

• AlphaFold DB: A0A5Z6V2D1