Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/ElaA-DUF1778 |
| Location | 110317..111120 | Replicon | plasmid p24399 |
| Accession | NZ_CP051369 | ||
| Organism | Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | HFS24_RS22985 | Protein ID | WP_219827451.1 |
| Coordinates | 110590..111120 (+) | Length | 177 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | A0A3I9EVV2 |
| Locus tag | HFS24_RS22980 | Protein ID | WP_001275014.1 |
| Coordinates | 110317..110586 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFS24_RS22950 (HFS24_22895) | 105719..105982 | + | 264 | Protein_115 | type II toxin-antitoxin system ParD family antitoxin | - |
| HFS24_RS22955 (HFS24_22900) | 105969..106265 | + | 297 | WP_219827448.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HFS24_RS22960 (HFS24_22905) | 106490..106756 | + | 267 | WP_258169268.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HFS24_RS22965 (HFS24_22910) | 106743..107039 | + | 297 | WP_219827449.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HFS24_RS22970 (HFS24_22915) | 107404..108144 | + | 741 | WP_219827450.1 | tyrosine-type recombinase/integrase | - |
| HFS24_RS22975 (HFS24_22920) | 108470..109462 | - | 993 | WP_219827536.1 | RepB family plasmid replication initiator protein | - |
| HFS24_RS22980 (HFS24_22925) | 110317..110586 | + | 270 | WP_001275014.1 | DUF1778 domain-containing protein | Antitoxin |
| HFS24_RS22985 (HFS24_22930) | 110590..111120 | + | 531 | WP_219827451.1 | GNAT family N-acetyltransferase | Toxin |
| HFS24_RS22990 (HFS24_22935) | 111362..111970 | + | 609 | WP_219827452.1 | DUF2913 family protein | - |
| HFS24_RS22995 (HFS24_22940) | 111967..112335 | - | 369 | WP_219827453.1 | hypothetical protein | - |
| HFS24_RS23000 (HFS24_22945) | 112653..112904 | + | 252 | WP_023213107.1 | plasmid stabilization protein | - |
| HFS24_RS23005 (HFS24_22950) | 112901..113218 | + | 318 | WP_096198112.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HFS24_RS23010 (HFS24_22955) | 113741..114607 | + | 867 | WP_080155185.1 | AAA family ATPase | - |
| HFS24_RS23015 (HFS24_22960) | 114607..115638 | + | 1032 | WP_219827454.1 | ParB/RepB/Spo0J family partition protein | - |
| HFS24_RS23020 (HFS24_22965) | 115638..116075 | + | 438 | WP_080155187.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..136285 | 136285 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 177 a.a. Molecular weight: 20353.16 Da Isoelectric Point: 6.2299
>T154029 WP_219827451.1 NZ_CP051369:110590-111120 [Salmonella enterica subsp. houtenae serovar 43:z4]
MDGLRIDIFSEEVEYELSNFDCGEEYLNTFLTDHLKRQHNSKILRGYLLVTREDKPRVMGYYTLSGSCFEKTLLPSKTQQ
KRVPYKNVPSVTLGRLAIDRSIHHQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKEFYLRLGFIQLKEENCNSL
FYPTKSVEELFEVKDE
MDGLRIDIFSEEVEYELSNFDCGEEYLNTFLTDHLKRQHNSKILRGYLLVTREDKPRVMGYYTLSGSCFEKTLLPSKTQQ
KRVPYKNVPSVTLGRLAIDRSIHHQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKEFYLRLGFIQLKEENCNSL
FYPTKSVEELFEVKDE
Download Length: 531 bp
>T154029 NZ_CP067303:2011828-2012004 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10257.64 Da Isoelectric Point: 5.7252
>AT154029 WP_001275014.1 NZ_CP051369:110317-110586 [Salmonella enterica subsp. houtenae serovar 43:z4]
MSALKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLLLNEESWNLVMDAITNPPAPNDRLKR
AANRLRELE
MSALKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLLLNEESWNLVMDAITNPPAPNDRLKR
AANRLRELE
Download Length: 270 bp
>AT154029 NZ_CP067303:2012050-2012466 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|