Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4045776..4046419 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HFS24_RS19450 Protein ID WP_000048133.1
Coordinates 4046003..4046419 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HFS24_RS19445 Protein ID WP_001261295.1
Coordinates 4045776..4046006 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS19435 (4042822) 4042822..4044960 + 2139 WP_000187810.1 anaerobic ribonucleoside-triphosphate reductase -
HFS24_RS19440 (4045145) 4045145..4045609 + 465 WP_001210950.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HFS24_RS19445 (4045776) 4045776..4046006 + 231 WP_001261295.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HFS24_RS19450 (4046003) 4046003..4046419 + 417 WP_000048133.1 type II toxin-antitoxin system VapC family toxin Toxin
HFS24_RS19455 (4046480) 4046480..4048393 - 1914 WP_001212155.1 BglG family transcription antiterminator -
HFS24_RS19460 (4048410) 4048410..4049150 - 741 WP_002955043.1 KDGP aldolase family protein -
HFS24_RS19465 (4049147) 4049147..4050265 - 1119 WP_219826953.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HFS24_RS19470 (4050249) 4050249..4051382 - 1134 WP_219826954.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15205.50 Da        Isoelectric Point: 8.1468

>T154026 WP_000048133.1 NZ_CP051368:4046003-4046419 [Salmonella enterica subsp. houtenae serovar 43:z4]
MSKTYMLDTCICSFIMREQPEAVLKHLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQRVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAASGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T154026 NZ_CP067303:c1819996-1819889 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8933.98 Da        Isoelectric Point: 4.6794

>AT154026 WP_001261295.1 NZ_CP051368:4045776-4046006 [Salmonella enterica subsp. houtenae serovar 43:z4]
MRTVSVFKNGNNRAIRLPRDLDFEGVNELEIFREGDTIILRPARPSWGSFRHEEKVNPDFLTEREDIVSDEGRFEL

Download         Length: 231 bp

>AT154026 NZ_CP067303:1820044-1820110 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References