Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411135..3411755 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HFS24_RS16465 Protein ID WP_001280991.1
Coordinates 3411537..3411755 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag HFS24_RS16460 Protein ID WP_000344807.1
Coordinates 3411135..3411509 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS16450 (3406272) 3406272..3407465 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HFS24_RS16455 (3407488) 3407488..3410637 + 3150 WP_001132514.1 efflux RND transporter permease AcrB -
HFS24_RS16460 (3411135) 3411135..3411509 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
HFS24_RS16465 (3411537) 3411537..3411755 + 219 WP_001280991.1 HHA domain-containing protein Toxin
HFS24_RS16470 (3411935) 3411935..3412487 + 553 Protein_3267 maltose O-acetyltransferase -
HFS24_RS16475 (3412604) 3412604..3413074 + 471 WP_000136184.1 YlaC family protein -
HFS24_RS16480 (3413129) 3413129..3413269 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
HFS24_RS16485 (3413275) 3413275..3413535 - 261 WP_000801413.1 type B 50S ribosomal protein L31 -
HFS24_RS16490 (3413760) 3413760..3415310 + 1551 WP_023186867.1 EAL domain-containing protein -
HFS24_RS16500 (3415541) 3415541..3415930 + 390 WP_219826812.1 MGMT family protein -
HFS24_RS16505 (3415963) 3415963..3416532 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T154025 WP_001280991.1 NZ_CP051368:3411537-3411755 [Salmonella enterica subsp. houtenae serovar 43:z4]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154025 NZ_CP067303:c1051011-1050793 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT154025 WP_000344807.1 NZ_CP051368:3411135-3411509 [Salmonella enterica subsp. houtenae serovar 43:z4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT154025 NZ_CP067303:c1051411-1051037 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References