Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2248761..2249518 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name tacT Uniprot ID A0A727YYP2
Locus tag HFS24_RS10780 Protein ID WP_000406362.1
Coordinates 2249036..2249518 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag HFS24_RS10775 Protein ID WP_001195098.1
Coordinates 2248761..2249045 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS10745 (2243800) 2243800..2244375 + 576 WP_001024330.1 YceI family protein -
HFS24_RS10750 (2244387) 2244387..2245589 + 1203 WP_219827389.1 lactate oxidase -
HFS24_RS10755 (2245636) 2245636..2246073 - 438 WP_000354864.1 cryptic aminoglycoside N-acetyltransferase AAC(6')-Iy/Iaa -
HFS24_RS10760 (2246073) 2246073..2246864 - 792 WP_219827390.1 DeoR/GlpR family DNA-binding transcription regulator -
HFS24_RS10765 (2246879) 2246879..2247301 - 423 Protein_2123 epimerase -
HFS24_RS10770 (2248249) 2248249..2248512 - 264 WP_023187453.1 hypothetical protein -
HFS24_RS10775 (2248761) 2248761..2249045 + 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
HFS24_RS10780 (2249036) 2249036..2249518 + 483 WP_000406362.1 GNAT family N-acetyltransferase Toxin
HFS24_RS23370 (2249523) 2249523..2249629 - 107 Protein_2127 ethanolamine utilization protein EutE -
HFS24_RS10785 (2249910) 2249910..2250359 + 450 WP_000750480.1 hypothetical protein -
HFS24_RS23375 (2250415) 2250415..2250501 - 87 Protein_2129 hypothetical protein -
HFS24_RS10795 (2250578) 2250578..2250916 + 339 WP_258169254.1 hypothetical protein -
HFS24_RS10800 (2250913) 2250913..2251041 + 129 Protein_2131 IS66 family insertion sequence element accessory protein TnpB -
HFS24_RS10805 (2251151) 2251151..2252182 + 1032 WP_219827356.1 IS630 family transposase -
HFS24_RS10810 (2252800) 2252800..2253336 + 537 WP_023186253.1 fimbrial protein -
HFS24_RS10815 (2253391) 2253391..2254122 + 732 WP_001117985.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2248761..2262502 13741
- inside IScluster/Tn aac(6')-Iaa - 2245636..2252182 6546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(13-88)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 18116.77 Da        Isoelectric Point: 7.0279

>T154024 WP_000406362.1 NZ_CP051368:2249036-2249518 [Salmonella enterica subsp. houtenae serovar 43:z4]
MEISVTAPELLHEEHDLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICLECTKRVVGYYSIATGSVSHASLGRRLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRISNLADQVGIKAIMVHAIDEQAKTFYEYFGFVHSPISPNTLFYKI

Download         Length: 483 bp

>T154024 NZ_CP067303:858393-858791 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10964.52 Da        Isoelectric Point: 9.6539

>AT154024 WP_001195098.1 NZ_CP051368:2248761-2249045 [Salmonella enterica subsp. houtenae serovar 43:z4]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT154024 NZ_CP067303:858097-858390 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727YYP2

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References