Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 785223..785883 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name cptA Uniprot ID A0A727YNG4
Locus tag HFS24_RS03715 Protein ID WP_000244760.1
Coordinates 785470..785883 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag HFS24_RS03710 Protein ID WP_000351186.1
Coordinates 785223..785489 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS03690 (781162) 781162..782595 - 1434 WP_219827116.1 6-phospho-beta-glucosidase -
HFS24_RS03695 (782752) 782752..783063 + 312 WP_001182974.1 N(4)-acetylcytidine aminohydrolase -
HFS24_RS03700 (783227) 783227..783886 + 660 WP_000250290.1 hemolysin III family protein -
HFS24_RS03705 (783994) 783994..784974 - 981 WP_002954437.1 tRNA-modifying protein YgfZ -
HFS24_RS03710 (785223) 785223..785489 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
HFS24_RS03715 (785470) 785470..785883 + 414 WP_000244760.1 protein YgfX Toxin
HFS24_RS03720 (785936) 785936..786457 - 522 WP_219827117.1 flavodoxin FldB -
HFS24_RS03725 (786570) 786570..787466 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
HFS24_RS03730 (787490) 787490..788203 + 714 WP_000745620.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HFS24_RS03735 (788209) 788209..789942 + 1734 WP_002954434.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16318.35 Da        Isoelectric Point: 11.1741

>T154012 WP_000244760.1 NZ_CP051368:785470-785883 [Salmonella enterica subsp. houtenae serovar 43:z4]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRIMLQQPISRQH

Download         Length: 414 bp

>T154012 NZ_CP067299:c3450531-3450196 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT154012 WP_000351186.1 NZ_CP051368:785223-785489 [Salmonella enterica subsp. houtenae serovar 43:z4]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154012 NZ_CP067299:c3450779-3450531 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727YNG4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References