Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 44908..45433 Replicon plasmid p28296-1
Accession NZ_CP051367
Organism Salmonella enterica subsp. enterica serovar Choleraesuis strain CVM 28296

Toxin (Protein)


Gene name ccdB Uniprot ID Q9EUE9
Locus tag HFS36_RS23385 Protein ID WP_001541545.1
Coordinates 44908..45213 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag HFS36_RS23390 Protein ID WP_000813641.1
Coordinates 45215..45433 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS36_RS23350 40310..40869 - 560 Protein_44 inverse autotransporter beta domain-containing protein -
HFS36_RS23355 41589..42074 - 486 WP_000905606.1 membrane protein -
HFS36_RS23360 42068..42577 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
HFS36_RS23365 42504..43272 - 769 Protein_47 EAL domain-containing protein -
HFS36_RS23370 43281..44063 - 783 WP_000082169.1 site-specific integrase -
HFS36_RS23375 44098..44619 - 522 WP_000198608.1 hypothetical protein -
HFS36_RS23380 44616..44906 - 291 WP_001266176.1 hypothetical protein -
HFS36_RS23385 44908..45213 - 306 WP_001541545.1 type II toxin-antitoxin system toxin CcdB Toxin
HFS36_RS23390 45215..45433 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HFS36_RS23395 46109..46630 + 522 WP_011264020.1 hypothetical protein -
HFS36_RS23400 46674..47102 - 429 Protein_54 hypothetical protein -
HFS36_RS23405 47114..47409 + 296 Protein_55 cytoplasmic protein -
HFS36_RS23410 47903..48892 + 990 WP_000461383.1 RepB family plasmid replication initiator protein -
HFS36_RS23415 49181..49342 - 162 WP_001541548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49582 49582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T154011 WP_001541545.1 NZ_CP051367:c45213-44908 [Salmonella enterica subsp. enterica serovar Choleraesuis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T154011 NZ_CP067299:c2623439-2623188 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT154011 WP_000813641.1 NZ_CP051367:c45433-45215 [Salmonella enterica subsp. enterica serovar Choleraesuis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT154011 NZ_CP067299:c2623191-2622937 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9EUE9

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References