Detailed information of TA system TA154010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 12286..12911
• Replicon: plasmid p28296-1
• Accession: NZ_CP051367
• Organism: Salmonella enterica subsp. enterica serovar Choleraesuis strain CVM 28296

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HFS36_RS23205
• Protein ID: WP_000911322.1
• Coordinates: 12513..12911 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: HFS36_RS23200
• Protein ID: WP_000450263.1
• Coordinates: 12286..12513 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS36_RS23175	7764..7919	-	156	WP_001719547.1	hypothetical protein	-
HFS36_RS23180	7935..8208	-	274	Protein_10	disulfide bond formation protein DsbA	-
HFS36_RS23185	8325..8888	-	564	WP_000139307.1	fertility inhibition protein FinO	-
HFS36_RS23190	8943..9683	-	741	WP_000177630.1	conjugal transfer pilus acetylase TraX	-
HFS36_RS23195	9703..12204	-	2502	Protein_13	conjugative relaxase	-
HFS36_RS23200	12286..12513	+	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin
HFS36_RS23205	12513..12911	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HFS36_RS23210	12920..15136	-	2217	WP_199275047.1	type IV conjugative transfer system coupling protein TraD	-
HFS36_RS23215	15508..16239	-	732	WP_001541558.1	complement resistance protein TraT	-
HFS36_RS23220	16542..16784	-	243	WP_024131413.1	hypothetical protein	-
HFS36_RS23225	16781..17482	-	702	WP_148201696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49582	49582

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T154010 WP_000911322.1 NZ_CP051367:12513-12911 [Salmonella enterica subsp. enterica serovar Choleraesuis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T154010 NZ_CP067299:c2623191-2622937 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT154010 WP_000450263.1 NZ_CP051367:12286-12513 [Salmonella enterica subsp. enterica serovar Choleraesuis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT154010 NZ_CP067299:c2623439-2623188 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA