Detailed information of TA system TA154008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 55227..55852
• Replicon: plasmid p28321b-2
• Accession: NZ_CP051364
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 28321-b

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HFS62_RS24095
• Protein ID: WP_000911322.1
• Coordinates: 55227..55625 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HFS62_RS24100
• Protein ID: WP_000450265.1
• Coordinates: 55625..55852 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS62_RS24055	50366..50632	+	267	WP_010999936.1	replication regulatory protein RepA	-
HFS62_RS24060	50882..50959	+	78	WP_001541552.1	RepA leader peptide Tap	-
HFS62_RS24065	50940..51821	+	882	WP_001738692.1	incFII family plasmid replication initiator RepA	-
HFS62_RS24070	52681..52902	+	222	WP_071533052.1	SdiA-regulated domain-containing protein	-
HFS62_RS24075	52999..53757	-	759	WP_000417898.1	AraC family transcriptional regulator	-
HFS62_RS24080	54024..54581	-	558	WP_000725062.1	complement resistance protein Rck	-
HFS62_RS24085	54671..54811	-	141	WP_000052148.1	SdiA-regulated domain-containing protein	-
HFS62_RS24090	54832..55218	+	387	Protein_68	conjugal transfer protein TraD	-
HFS62_RS24095	55227..55625	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HFS62_RS24100	55625..55852	-	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..107602	107602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T154008 WP_000911322.1 NZ_CP051364:c55625-55227 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T154008 NZ_CP067299:c2458220-2458117 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT154008 WP_000450265.1 NZ_CP051364:c55852-55625 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT154008 NZ_CP067299:2458079-2458350 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT