Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 14574..15175 Replicon plasmid p28322-3
Accession NZ_CP051361
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain CVM 28322

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag HFS63_RS25750 Protein ID WP_001216045.1
Coordinates 14574..14954 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag HFS63_RS25755 Protein ID WP_001190712.1
Coordinates 14954..15175 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS63_RS25725 10015..11499 - 1485 WP_000124159.1 hypothetical protein -
HFS63_RS25730 11499..12692 - 1194 WP_000219618.1 hypothetical protein -
HFS63_RS25735 12778..13230 - 453 WP_001326849.1 late promoter-activating protein -
HFS63_RS25740 13319..14362 - 1044 WP_000648833.1 DUF968 domain-containing protein -
HFS63_RS25745 14390..14569 - 180 WP_000113018.1 hypothetical protein -
HFS63_RS25750 14574..14954 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HFS63_RS25755 14954..15175 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HFS63_RS25760 15248..15637 - 390 WP_000506726.1 DNA repair protein -
HFS63_RS25765 15761..16012 - 252 WP_046644566.1 DNA polymerase III subunit theta -
HFS63_RS25770 16461..16598 + 138 WP_000123562.1 hypothetical protein -
HFS63_RS25775 16673..17035 - 363 WP_001261544.1 hypothetical protein -
HFS63_RS25780 17032..17964 - 933 WP_077947608.1 hypothetical protein -
HFS63_RS25785 17946..18320 - 375 WP_023356289.1 hypothetical protein -
HFS63_RS25790 18327..18620 - 294 WP_000269004.1 hypothetical protein -
HFS63_RS25795 18799..19032 - 234 WP_000516537.1 hypothetical protein -
HFS63_RS25800 19115..19996 - 882 WP_058820836.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95358 95358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 18709.44 Da        Isoelectric Point: 5.5500

>T154006 WP_001216045.1 NZ_CP051361:c14954-14574 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 381 bp

>T154006 NZ_CP067299:c2120417-2119095 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 10909.08 Da        Isoelectric Point: 5.5500

>AT154006 WP_001190712.1 NZ_CP051361:c15175-14954 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 222 bp

>AT154006 NZ_CP067299:c2120683-2120417 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References