Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 79391..81014 Replicon plasmid p28322-1
Accession NZ_CP051359
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain CVM 28322

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HFS63_RS23935 Protein ID WP_000088046.1
Coordinates 79391..80716 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HFS63_RS23940 Protein ID WP_024136327.1
Coordinates 80721..81014 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS63_RS23910 75789..76493 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HFS63_RS23915 77105..77530 - 426 WP_001043843.1 hypothetical protein -
HFS63_RS23920 77784..78599 - 816 WP_001572439.1 HNH endonuclease -
HFS63_RS23925 78612..79022 - 411 WP_000985911.1 hypothetical protein -
HFS63_RS23930 79124..79330 - 207 WP_000134171.1 hypothetical protein -
HFS63_RS23935 79391..80716 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HFS63_RS23940 80721..81014 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HFS63_RS23945 81618..82010 - 393 WP_000341066.1 hypothetical protein -
HFS63_RS23950 82383..82724 + 342 WP_001151575.1 hypothetical protein -
HFS63_RS23955 82816..83007 + 192 WP_000398480.1 hypothetical protein -
HFS63_RS23960 83057..83338 + 282 WP_000077926.1 hypothetical protein -
HFS63_RS23965 83901..85142 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..234536 234536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 65070.07 Da        Isoelectric Point: 5.5500

>T154004 WP_000088046.1 NZ_CP051359:c80716-79391 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 1326 bp

>T154004 NZ_CP067299:c1844244-1844137 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 14441.32 Da        Isoelectric Point: 5.5500

>AT154004 WP_024136327.1 NZ_CP051359:c81014-80721 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Download         Length: 294 bp

>AT154004 NZ_CP067299:1844291-1844357 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References