Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 632..1179 Replicon plasmid p30148-1
Accession NZ_CP051354
Organism Salmonella enterica subsp. enterica serovar Worthington strain CVM 30148

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag HFS90_RS24190 Protein ID WP_000969996.1
Coordinates 898..1179 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag HFS90_RS24185 Protein ID WP_000079928.1
Coordinates 632..901 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS90_RS24185 632..901 + 270 WP_000079928.1 hypothetical protein Antitoxin
HFS90_RS24190 898..1179 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFS90_RS24195 1219..2067 + 849 WP_001057996.1 3'-5' exonuclease -
HFS90_RS24200 2304..2462 - 159 WP_197711125.1 MerR family transcriptional regulator -
HFS90_RS24205 2424..3605 + 1182 Protein_4 transposase -
HFS90_RS24210 3670..4374 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HFS90_RS24215 4447..4686 + 240 WP_011264039.1 macrolide transporter -
HFS90_RS24220 4832..5695 + 864 WP_000612791.1 SDR family oxidoreductase -
HFS90_RS24225 5733..5978 + 246 WP_001354008.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..104600 104600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T154002 WP_000969996.1 NZ_CP051354:898-1179 [Salmonella enterica subsp. enterica serovar Worthington]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T154002 NZ_CP067299:c1843174-1843067 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT154002 WP_000079928.1 NZ_CP051354:632-901 [Salmonella enterica subsp. enterica serovar Worthington]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT154002 NZ_CP067299:1843222-1843288 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References