Detailed information of TA system TA154001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 72493..73040
• Replicon: plasmid p30168-1
• Accession: NZ_CP051351
• Organism: Salmonella enterica subsp. enterica serovar Schwarzengrund strain CVM 30168

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HFT09_RS22755
• Protein ID: WP_000969983.1
• Coordinates: 72493..72774 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5JBQ7
• Locus tag: HFT09_RS22760
• Protein ID: WP_000079943.1
• Coordinates: 72771..73040 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFT09_RS22740	69835..70392	+	558	WP_001217881.1	recombinase family protein	-
HFT09_RS22745	70575..71435	+	861	WP_000027057.1	class A broad-spectrum beta-lactamase TEM-1	-
HFT09_RS22750	71599..72447	-	849	WP_001058012.1	3'-5' exonuclease	-
HFT09_RS22755	72493..72774	-	282	WP_000969983.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFT09_RS22760	72771..73040	-	270	WP_000079943.1	hypothetical protein	Antitoxin
HFT09_RS22765	73948..74979	-	1032	WP_000907875.1	replication initiation protein	-
HFT09_RS22770	75952..76215	+	264	WP_001324596.1	ash family protein	-
HFT09_RS22775	76133..76420	+	288	WP_000074849.1	conjugal transfer protein TraA	-
HFT09_RS22780	76862..77395	+	534	WP_001303319.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..109942	109942

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T154001 WP_000969983.1 NZ_CP051351:c72774-72493 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T154001 NZ_CP067299:c1051011-1050793 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT154001 WP_000079943.1 NZ_CP051351:c73040-72771 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT154001 NZ_CP067299:c1051411-1051037 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A622US83