Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 35531..36056 | Replicon | plasmid p30177-2 |
| Accession | NZ_CP051348 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain CVM 30177 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | F0JY91 |
| Locus tag | HFT18_RS23700 | Protein ID | WP_001159869.1 |
| Coordinates | 35531..35836 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | H9TJP1 |
| Locus tag | HFT18_RS23705 | Protein ID | WP_000813630.1 |
| Coordinates | 35838..36056 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFT18_RS23670 | 31012..31446 | + | 435 | WP_000525034.1 | IS200/IS605 family transposase | - |
| HFT18_RS23675 | 31658..33031 | + | 1374 | WP_000244368.1 | IS4 family transposase | - |
| HFT18_RS23680 | 33131..34180 | - | 1050 | Protein_30 | IS4 family transposase | - |
| HFT18_RS23685 | 34180..34317 | - | 138 | Protein_31 | Lrp/AsnC family transcriptional regulator | - |
| HFT18_RS23690 | 34434..35345 | + | 912 | WP_000549737.1 | DMT family transporter | - |
| HFT18_RS23695 | 35330..35530 | - | 201 | Protein_33 | phage integrase family protein | - |
| HFT18_RS23700 | 35531..35836 | - | 306 | WP_001159869.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| HFT18_RS23705 | 35838..36056 | - | 219 | WP_000813630.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| HFT18_RS23710 | 37115..37351 | + | 237 | Protein_36 | hypothetical protein | - |
| HFT18_RS23715 | 37422..37826 | + | 405 | WP_000839181.1 | IS66 family insertion sequence hypothetical protein | - |
| HFT18_RS23720 | 37823..38170 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HFT18_RS23725 | 38219..39757 | + | 1539 | WP_000099202.1 | IS66-like element ISEc22 family transposase | - |
| HFT18_RS23730 | 39796..40032 | + | 237 | Protein_40 | hypothetical protein | - |
| HFT18_RS23735 | 40095..40691 | + | 597 | Protein_41 | IS66 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..48581 | 48581 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 15030.03 Da Isoelectric Point: 5.5500
>T154000 WP_001159869.1 NZ_CP051348:c35836-35531 [Salmonella enterica subsp. enterica serovar Kentucky]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
Download Length: 306 bp
>T154000 NZ_CP067299:858393-858791 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 10761.91 Da Isoelectric Point: 5.5500
>AT154000 WP_000813630.1 NZ_CP051348:c36056-35838 [Salmonella enterica subsp. enterica serovar Kentucky]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 219 bp
>AT154000 NZ_CP067299:858097-858390 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2SIB9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CEF5 |