Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 139001..139548 Replicon plasmid p30177-1
Accession NZ_CP051347
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM 30177

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag HFT18_RS23485 Protein ID WP_000969996.1
Coordinates 139001..139282 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HFT18_RS23490 Protein ID WP_000079941.1
Coordinates 139279..139548 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFT18_RS23460 134689..135036 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
HFT18_RS23465 135033..135437 - 405 WP_000839181.1 IS66 family insertion sequence hypothetical protein -
HFT18_RS23470 135684..136019 + 336 WP_001080729.1 colicin 1A immunity protein -
HFT18_RS23475 136041..137921 - 1881 WP_001283335.1 colicin -
HFT18_RS23480 138107..138955 - 849 WP_001057989.1 3'-5' exonuclease -
HFT18_RS23485 139001..139282 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFT18_RS23490 139279..139548 - 270 WP_000079941.1 hypothetical protein Antitoxin
HFT18_RS23495 140464..141321 - 858 WP_000130940.1 incFII family plasmid replication initiator RepA -
HFT18_RS23500 141314..141388 - 75 WP_001365705.1 RepA leader peptide Tap -
HFT18_RS23505 141627..141881 - 255 WP_000083830.1 replication regulatory protein RepA -
HFT18_RS23510 142203..143039 - 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
HFT18_RS23515 143039..143842 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146811 146811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T153999 WP_000969996.1 NZ_CP051347:c139282-139001 [Salmonella enterica subsp. enterica serovar Kentucky]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T153999 NZ_CP067299:c852331-852053 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 13263.91 Da        Isoelectric Point: 5.5500

>AT153999 WP_000079941.1 NZ_CP051347:c139548-139279 [Salmonella enterica subsp. enterica serovar Kentucky]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Download         Length: 270 bp

>AT153999 NZ_CP067299:c852594-852334 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References