Detailed information of TA system TA153994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 59319..59866
• Replicon: plasmid p35153
• Accession: NZ_CP051314
• Organism: Salmonella enterica subsp. enterica serovar London strain CVM 35153

Toxin (Protein)

• Gene name: parE
• Uniprot ID: W0LWB3
• Locus tag: HFU13_RS22875
• Protein ID: WP_000970007.1
• Coordinates: 59319..59600 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: HFU13_RS22880
• Protein ID: WP_000079941.1
• Coordinates: 59597..59866 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFU13_RS22845	54708..55592	-	885	Protein_66	hypothetical protein	-
HFU13_RS22850	55946..56548	+	603	WP_000517695.1	hypothetical protein	-
HFU13_RS22855	56604..57098	+	495	WP_001459505.1	hypothetical protein	-
HFU13_RS22860	57098..57364	+	267	WP_000955263.1	hypothetical protein	-
HFU13_RS22865	57841..58314	-	474	WP_001334658.1	hypothetical protein	-
HFU13_RS22870	58431..59279	-	849	WP_001057992.1	3'-5' exonuclease	-
HFU13_RS22875	59319..59600	-	282	WP_000970007.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFU13_RS22880	59597..59866	-	270	WP_000079941.1	hypothetical protein	Antitoxin
HFU13_RS22885	60775..61806	-	1032	WP_000907873.1	replication initiation protein	-
HFU13_RS22890	62779..63042	+	264	WP_001324596.1	ash family protein	-
HFU13_RS22895	62960..63247	+	288	WP_000074849.1	conjugal transfer protein TraA	-
HFU13_RS22900	63689..64222	+	534	WP_001303319.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102373	102373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T153994 WP_000970007.1 NZ_CP051314:c59600-59319 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T153994 NZ_CP067266:c269063-268605 [Escherichia coli]
GTGATCCTTTACCGACTGACCAAGACCCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCGAAAGAAACGGGGGGCCG
CTGGAACAGCGTAGGCACTGCAATGGTCTACCTGTCTGAAACGGCCAGCCTTACCATGCTTGAAACGCTGGTACACATTC
ACGCGCCGCAGTTACTGGACGACTTTACACTGCTGAGTCTTGATGTACCGGATGATCAGATCCAGACCTTCGACATGAGC
CGTCTCCCTGATAACTGGGCGAGTGAGGATGCTCCTGCTGAGCTGGCGCTCTACGGTGATAACTGGGCTGAAAGCGGTTC
TTCTATCGCGCTGCGTATTCCAAGTGCGTTGTCTCCGGTTGAATTTAACTACTTGCTGAATCCGGCACACCCTGAACTCT
TTGACCTGATGGCTACGGTTAAGAAAATTCCGTTCCGGTTTGATTCCCGCCTGAAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT153994 WP_000079941.1 NZ_CP051314:c59866-59597 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT153994 NZ_CP067266:c269506-269060 [Escherichia coli]
ATGACGATGAAAGTTTTTTCTCCAGACGTTACCAAAACGAATCAGCACTGCTTATGGCAGGTTGCTGGGCTGGATAATGA
CGGTATCGCGCTGATGGATAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCTGAATGGGCTAACATCA
CGCCGTCTGAGCTGCGCAAAATGTCGGGTATACCTAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGAT
CAGAGCGAACGTCTGGTGCGCATTATCCGCGTAATTGAACGCGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCGGCGCA
CAAATGGCTGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGCTTGTTTCTTCTGAGACAGGTGCGCTTG
AAGTGATGCGCCTGATTACGCGTATTGAGCACGGGGTATACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A7G1GDN5

Antitoxin

• AlphaFold DB: A0A629TXC5