Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 40112..40637 Replicon plasmid p35153
Accession NZ_CP051314
Organism Salmonella enterica subsp. enterica serovar London strain CVM 35153

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag HFU13_RS22750 Protein ID WP_001159871.1
Coordinates 40112..40417 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag HFU13_RS22755 Protein ID WP_000813630.1
Coordinates 40419..40637 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFU13_RS22725 36283..36699 - 417 WP_001278818.1 plasmid partitioning/stability family protein -
HFU13_RS22730 36692..37672 - 981 WP_000688514.1 plasmid segregation protein ParM -
HFU13_RS22735 38086..38394 - 309 WP_000030199.1 hypothetical protein -
HFU13_RS22740 38481..39125 - 645 WP_001144036.1 ParA family protein -
HFU13_RS22745 39305..40111 - 807 WP_000016969.1 site-specific integrase -
HFU13_RS22750 40112..40417 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
HFU13_RS22755 40419..40637 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HFU13_RS22760 41195..42121 + 927 WP_001290416.1 hypothetical protein -
HFU13_RS22765 42166..42420 + 255 WP_000678527.1 hypothetical protein -
HFU13_RS22770 42919..43263 + 345 WP_000793307.1 hypothetical protein -
HFU13_RS22775 43439..44440 - 1002 WP_000774875.1 DUF4238 domain-containing protein -
HFU13_RS22780 44792..45046 + 255 WP_000343103.1 hypothetical protein -
HFU13_RS22785 45046..45636 + 591 WP_000194550.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102373 102373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T153993 WP_001159871.1 NZ_CP051314:c40417-40112 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T153993 NZ_CP067266:c112171-111863 [Escherichia coli]
ATGCAATATACCGTTTACCGCAATCCCGGCAACAGCCAGGCATACCCTTACCTGCTGGATATACAGAGCGACATCATTGG
CGAGTTAAATACCCGCCTGGTGATCCCCCTTCATCGGCTTAAAAAAGGAGCCTCGGCCCCGGTTGCGCGATTAACTCCGG
TCATACAGGTGGAAGGGAATGACGTTATCCTGATGACGCATGAAATGGCTTCAGTCCGCGTGAAGCAGCTCGGTCAGGCG
GTCATGGACGCATCTCCGTTCCGGCACACTATCAAAAGTGCGGTGGACTTCCTGCTGGATGGTTTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT153993 WP_000813630.1 NZ_CP051314:c40637-40419 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT153993 NZ_CP067266:c112413-112174 [Escherichia coli]
ATGCAGGCTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACCCTTGAGCCAATGCTCGTACAGCAGGCAAAAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCAGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References