Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 57227..57774 Replicon plasmid p35161-2
Accession NZ_CP051312
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain CVM 35161

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag HFU19_RS25065 Protein ID WP_000970007.1
Coordinates 57493..57774 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HFU19_RS25060 Protein ID WP_000079941.1
Coordinates 57227..57496 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFU19_RS25040 52871..53404 - 534 WP_001303319.1 transcription termination factor NusG -
HFU19_RS25045 53846..54133 - 288 WP_000074849.1 conjugal transfer protein TraA -
HFU19_RS25050 54051..54314 - 264 WP_001324596.1 ash family protein -
HFU19_RS25055 55287..56318 + 1032 WP_000907873.1 replication initiation protein -
HFU19_RS25060 57227..57496 + 270 WP_000079941.1 hypothetical protein Antitoxin
HFU19_RS25065 57493..57774 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFU19_RS25070 57814..58662 + 849 WP_001057991.1 3'-5' exonuclease -
HFU19_RS25075 58779..59246 + 468 Protein_58 hypothetical protein -
HFU19_RS25080 59728..59994 - 267 WP_000955263.1 hypothetical protein -
HFU19_RS25085 59994..60488 - 495 WP_001459505.1 hypothetical protein -
HFU19_RS25090 60544..61146 - 603 WP_000517695.1 hypothetical protein -
HFU19_RS25095 61500..62384 + 885 Protein_62 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101468 101468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T153991 WP_000970007.1 NZ_CP051312:57493-57774 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T153991 NZ_CP067265:3811007-3811414 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT153991 WP_000079941.1 NZ_CP051312:57227-57496 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT153991 NZ_CP067265:3810760-3811026 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References