Detailed information of TA system TA153988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2485330..2485955
• Replicon: chromosome
• Accession: NZ_CP051305
• Organism: Treponema sp. OMZ 798

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4O07_RS11495
• Protein ID: WP_253685960.1
• Coordinates: 2485330..2485725 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E4O07_RS11500
• Protein ID: WP_253685962.1
• Coordinates: 2485725..2485955 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O07_RS11485 (E4O07_11510)	2481728..2484265	+	2538	WP_253685956.1	ribonucleoside-diphosphate reductase subunit alpha	-
E4O07_RS11490 (E4O07_11515)	2484319..2485206	-	888	WP_253685958.1	fructose bisphosphate aldolase	-
E4O07_RS11495 (E4O07_11520)	2485330..2485725	-	396	WP_253685960.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4O07_RS11500 (E4O07_11525)	2485725..2485955	-	231	WP_253685962.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
E4O07_RS11505 (E4O07_11530)	2486092..2488143	+	2052	WP_253685964.1	elongation factor G	-
E4O07_RS11510 (E4O07_11535)	2488176..2489789	-	1614	WP_253685966.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15105.72 Da
• Isoelectric Point: 9.9512

>T153988 WP_253685960.1 NZ_CP051305:c2485725-2485330 [Treponema sp. OMZ 798]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYVEKNRISLIKFLTPFSILNFDDRDAQEFG
KIRTSLKTEGKIIGAYDMLIAAQAIAKNLILVTNNTKEFCRIKNLNLEDWK

Nucleotide

• Length: 396 bp

>T153988 NZ_CP067265:c3568891-3568427 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8904.02 Da
• Isoelectric Point: 4.8278

>AT153988 WP_253685962.1 NZ_CP051305:c2485955-2485725 [Treponema sp. OMZ 798]
METAKLFRNGRSQAVRLPKEYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMEEGRCQPDLQDRKDL

Nucleotide

• Length: 231 bp

>AT153988 NZ_CP067265:c3569226-3568891 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA