Detailed information of TA system TA153986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2327320..2327870
• Replicon: chromosome
• Accession: NZ_CP051304
• Organism: Treponema denticola strain CD-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QD8
• Locus tag: E4N79_RS10950
• Protein ID: WP_002665928.1
• Coordinates: 2327589..2327870 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: E4N79_RS10945
• Protein ID: WP_002665927.1
• Coordinates: 2327320..2327592 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N79_RS10900 (E4N79_10890)	2322713..2323027	+	315	WP_002665898.1	hypothetical protein	-
E4N79_RS10905 (E4N79_10895)	2323289..2324065	+	777	WP_253688680.1	hypothetical protein	-
E4N79_RS10910 (E4N79_10900)	2324092..2324415	+	324	WP_010693403.1	hypothetical protein	-
E4N79_RS10915 (E4N79_10905)	2324521..2325321	+	801	WP_253688681.1	DUF4261 domain-containing protein	-
E4N79_RS10920 (E4N79_10910)	2325398..2325556	+	159	WP_253688682.1	hypothetical protein	-
E4N79_RS10925 (E4N79_10915)	2325608..2325757	+	150	WP_253688683.1	hypothetical protein	-
E4N79_RS10930 (E4N79_10920)	2325759..2326430	+	672	WP_253688684.1	hypothetical protein	-
E4N79_RS10935 (E4N79_10925)	2326486..2327055	+	570	WP_253688685.1	hypothetical protein	-
E4N79_RS10940 (E4N79_10930)	2327060..2327254	+	195	WP_253688686.1	hypothetical protein	-
E4N79_RS10945 (E4N79_10935)	2327320..2327592	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N79_RS10950 (E4N79_10940)	2327589..2327870	+	282	WP_002665928.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N79_RS10955 (E4N79_10945)	2327933..2328568	+	636	WP_253688687.1	hypothetical protein	-
E4N79_RS10960 (E4N79_10950)	2328606..2329457	+	852	WP_253688688.1	DUF2262 domain-containing protein	-
E4N79_RS10965 (E4N79_10955)	2329477..2329884	+	408	WP_253688689.1	hypothetical protein	-
E4N79_RS10970 (E4N79_10960)	2329976..2331040	+	1065	WP_253688690.1	ankyrin repeat domain-containing protein	-
E4N79_RS10975 (E4N79_10965)	2331223..2332350	+	1128	WP_253688691.1	hypothetical protein	-
E4N79_RS10980 (E4N79_10970)	2332467..2332844	+	378	WP_253688692.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11113.98 Da
• Isoelectric Point: 9.8023

>T153986 WP_002665928.1 NZ_CP051304:2327589-2327870 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T153986 NZ_CP067265:c2471971-2471798 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT153986 WP_002665927.1 NZ_CP051304:2327320-2327592 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT153986 NZ_CP067265:c2472295-2471999 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: Q73QD8

Antitoxin

• AlphaFold DB: Q73QD7