Detailed information of TA system TA153985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 2178464..2178989
• Replicon: chromosome
• Accession: NZ_CP051304
• Organism: Treponema denticola strain CD-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: M2SKE4
• Locus tag: E4N79_RS10145
• Protein ID: WP_002677039.1
• Coordinates: 2178726..2178989 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: E4N79_RS10140
• Protein ID: WP_002677040.1
• Coordinates: 2178464..2178721 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N79_RS10135 (E4N79_10130)	2176873..2178141	-	1269	WP_253688577.1	OmpA family protein	-
E4N79_RS10140 (E4N79_10135)	2178464..2178721	+	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N79_RS10145 (E4N79_10140)	2178726..2178989	+	264	WP_002677039.1	Txe/YoeB family addiction module toxin	Toxin
E4N79_RS10150 (E4N79_10145)	2179104..2179382	+	279	WP_253688578.1	antitoxin	-
E4N79_RS10155 (E4N79_10150)	2179366..2179773	+	408	WP_002677037.1	type II toxin-antitoxin system VapC family toxin	-
E4N79_RS10160 (E4N79_10155)	2180155..2180370	+	216	WP_002672335.1	hypothetical protein	-
E4N79_RS10165 (E4N79_10160)	2180367..2180762	+	396	WP_002672336.1	PIN domain-containing protein	-
E4N79_RS10170 (E4N79_10165)	2180816..2181721	+	906	WP_002669905.1	YafY family protein	-
E4N79_RS10175 (E4N79_10170)	2181798..2182310	+	513	WP_253688579.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10419.98 Da
• Isoelectric Point: 9.7704

>T153985 WP_002677039.1 NZ_CP051304:2178726-2178989 [Treponema denticola]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIVDNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T153985 NZ_CP067265:1954085-1954363 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT153985 WP_002677040.1 NZ_CP051304:2178464-2178721 [Treponema denticola]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT153985 NZ_CP067265:1953822-1954082 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: M2SKE4

Antitoxin

• AlphaFold DB: Q73PY2