Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 623324..623909 Replicon chromosome
Accession NZ_CP051304
Organism Treponema denticola strain CD-1

Toxin (Protein)


Gene name hicA Uniprot ID E9S222
Locus tag E4N79_RS02845 Protein ID WP_002668014.1
Coordinates 623652..623909 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q73KK4
Locus tag E4N79_RS02840 Protein ID WP_002668012.1
Coordinates 623324..623659 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N79_RS02825 (E4N79_02825) 618784..619995 + 1212 WP_002674469.1 substrate-binding domain-containing protein -
E4N79_RS02830 (E4N79_02830) 620106..621599 + 1494 WP_253689342.1 sugar ABC transporter ATP-binding protein -
E4N79_RS02835 (E4N79_02835) 621624..623318 + 1695 WP_253689343.1 galactoside ABC transporter permease -
E4N79_RS02840 (E4N79_02840) 623324..623659 - 336 WP_002668012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N79_RS02845 (E4N79_02845) 623652..623909 - 258 WP_002668014.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N79_RS02850 (E4N79_02850) 624078..625277 + 1200 WP_253689344.1 galactokinase -
E4N79_RS02855 (E4N79_02855) 625467..626066 + 600 WP_253689345.1 hypothetical protein -
E4N79_RS02860 (E4N79_02860) 626082..627389 + 1308 WP_253689346.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9589.93 Da        Isoelectric Point: 10.6118

>T153983 WP_002668014.1 NZ_CP051304:c623909-623652 [Treponema denticola]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Download         Length: 258 bp

>T153983 NZ_CP067265:1937503-1937844 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12628.35 Da        Isoelectric Point: 4.9348

>AT153983 WP_002668012.1 NZ_CP051304:c623659-623324 [Treponema denticola]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Download         Length: 336 bp

>AT153983 NZ_CP067265:1937153-1937482 [Escherichia coli]
GTGGAGAACTGTAATGAGCAACCCTACCAGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGA
AGGCAACCGACTGCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATG
AAACATTCCCGCACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTT
ACCCTGTACCACAACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCAC
TCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9S222

Antitoxin

Source ID Structure
AlphaFold DB Q73KK4

References