Detailed information of TA system TA153982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2499604..2500160
• Replicon: chromosome
• Accession: NZ_CP051303
• Organism: Treponema denticola strain OT2B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M2BB64
• Locus tag: E4N91_RS11610
• Protein ID: WP_002687374.1
• Coordinates: 2499604..2499885 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QZ1
• Locus tag: E4N91_RS11615
• Protein ID: WP_002676649.1
• Coordinates: 2499882..2500160 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N91_RS11595 (E4N91_11590)	2495636..2496742	+	1107	WP_253704046.1	redox-regulated ATPase YchF	-
E4N91_RS11600 (E4N91_11595)	2496925..2498481	-	1557	WP_002687370.1	hypothetical protein	-
E4N91_RS11605 (E4N91_11600)	2498607..2499230	-	624	WP_002687372.1	hypothetical protein	-
E4N91_RS11610 (E4N91_11605)	2499604..2499885	-	282	WP_002687374.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N91_RS11615 (E4N91_11610)	2499882..2500160	-	279	WP_002676649.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N91_RS11620 (E4N91_11615)	2500233..2501036	-	804	WP_002687376.1	class I SAM-dependent methyltransferase	-
E4N91_RS11625 (E4N91_11620)	2501110..2502540	-	1431	WP_002687378.1	leucyl aminopeptidase	-
E4N91_RS11630 (E4N91_11625)	2502736..2503635	+	900	WP_002687380.1	glutamate formimidoyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10832.71 Da
• Isoelectric Point: 10.0731

>T153982 WP_002687374.1 NZ_CP051303:c2499885-2499604 [Treponema denticola]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKDIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Nucleotide

• Length: 282 bp

>T153982 NZ_CP067265:1749335-1749553 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10223.83 Da
• Isoelectric Point: 6.2705

>AT153982 WP_002676649.1 NZ_CP051303:c2500160-2499882 [Treponema denticola]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Nucleotide

• Length: 279 bp

>AT153982 NZ_CP067265:1748935-1749309 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: M2BB64

Antitoxin

• AlphaFold DB: Q73QZ1