Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2280285..2280835 Replicon chromosome
Accession NZ_CP051303
Organism Treponema denticola strain OT2B

Toxin (Protein)


Gene name relE Uniprot ID M2CGV3
Locus tag E4N91_RS10635 Protein ID WP_002687091.1
Coordinates 2280554..2280835 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73QD7
Locus tag E4N91_RS10630 Protein ID WP_002665927.1
Coordinates 2280285..2280557 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N91_RS10595 (E4N91_10590) 2276253..2276576 + 324 WP_253704006.1 hypothetical protein -
E4N91_RS10600 (E4N91_10595) 2276755..2277483 + 729 WP_253704007.1 DUF4261 domain-containing protein -
E4N91_RS10605 (E4N91_10600) 2277560..2277718 + 159 WP_010956759.1 hypothetical protein -
E4N91_RS10610 (E4N91_10605) 2277921..2278577 + 657 WP_253704008.1 hypothetical protein -
E4N91_RS10615 (E4N91_10610) 2278629..2279198 + 570 WP_253704009.1 hypothetical protein -
E4N91_RS10620 (E4N91_10615) 2279243..2279959 + 717 WP_253704010.1 hypothetical protein -
E4N91_RS10625 (E4N91_10620) 2280010..2280219 + 210 WP_002687090.1 hypothetical protein -
E4N91_RS10630 (E4N91_10625) 2280285..2280557 + 273 WP_002665927.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4N91_RS10635 (E4N91_10630) 2280554..2280835 + 282 WP_002687091.1 type II toxin-antitoxin system YafQ family toxin Toxin
E4N91_RS10640 (E4N91_10635) 2280863..2281222 + 360 WP_002687092.1 hypothetical protein -
E4N91_RS10645 (E4N91_10640) 2281215..2281838 + 624 WP_253704011.1 hypothetical protein -
E4N91_RS10650 (E4N91_10645) 2281876..2282727 + 852 WP_002687094.1 DUF2262 domain-containing protein -
E4N91_RS10655 (E4N91_10650) 2282749..2283813 + 1065 WP_002687095.1 ankyrin repeat domain-containing protein -
E4N91_RS10660 (E4N91_10655) 2283996..2285123 + 1128 WP_002687097.1 hypothetical protein -
E4N91_RS10665 (E4N91_10660) 2285228..2285617 + 390 WP_002687108.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-89)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11113.98 Da        Isoelectric Point: 9.8023

>T153981 WP_002687091.1 NZ_CP051303:2280554-2280835 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLFKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELLKK

Download         Length: 282 bp

>T153981 NZ_CP067265:934094-934201 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10205.78 Da        Isoelectric Point: 5.1486

>AT153981 WP_002665927.1 NZ_CP051303:2280285-2280557 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Download         Length: 273 bp

>AT153981 NZ_CP067265:c934047-933981 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M2CGV3

Antitoxin

Source ID Structure
AlphaFold DB Q73QD7

References