Detailed information of TA system TA153980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 2136000..2136525
• Replicon: chromosome
• Accession: NZ_CP051303
• Organism: Treponema denticola strain OT2B

Toxin (Protein)

• Gene name: relB
• Uniprot ID: M2CK18
• Locus tag: E4N91_RS09835
• Protein ID: WP_002685473.1
• Coordinates: 2136262..2136525 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: E4N91_RS09830
• Protein ID: WP_002677040.1
• Coordinates: 2136000..2136257 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N91_RS09825 (E4N91_09815)	2134399..2135667	-	1269	WP_002686860.1	OmpA family protein	-
E4N91_RS09830 (E4N91_09820)	2136000..2136257	+	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N91_RS09835 (E4N91_09825)	2136262..2136525	+	264	WP_002685473.1	Txe/YoeB family addiction module toxin	Toxin
E4N91_RS09840 (E4N91_09830)	2136640..2136918	+	279	WP_002669909.1	antitoxin	-
E4N91_RS09845 (E4N91_09835)	2136902..2137309	+	408	WP_002686861.1	type II toxin-antitoxin system VapC family toxin	-
E4N91_RS09850 (E4N91_09840)	2137691..2137906	+	216	WP_002672335.1	hypothetical protein	-
E4N91_RS09855 (E4N91_09845)	2137903..2138298	+	396	WP_002672336.1	PIN domain-containing protein	-
E4N91_RS09860 (E4N91_09850)	2138352..2139257	+	906	WP_002686862.1	YafY family protein	-
E4N91_RS09865 (E4N91_09855)	2139334..2139846	+	513	WP_002686863.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10391.93 Da
• Isoelectric Point: 9.7704

>T153980 WP_002685473.1 NZ_CP051303:2136262-2136525 [Treponema denticola]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIADNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T153980 NZ_CP051303:2136262-2136525 [Treponema denticola]
ATGATTAAAGCATGGGATGAAGATGCATGGATAGATTATGTCTATTGGCAAACAGAAGATAAAAAAACACTAAAAAGAAT
CAATATGTTGATTAAAGATATTGAAAGGAATGGTCACAATGGTTTAGGCAGCCCTGAGCCATTAAAGGGAAATCTGTCAG
GATTCTGGAGCCGCAGGATAGATAAAAAAAATAGATTGGTTTATAGAATAGCCGATAATGTAATACAAATAATTCAGTGT
AGAACCCATTATGGTGAAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT153980 WP_002677040.1 NZ_CP051303:2136000-2136257 [Treponema denticola]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT153980 NZ_CP051303:2136000-2136257 [Treponema denticola]
ATGGCTCAAATAAATGTCAACATAAGAATGGATTCCGAAGTAAAACAAGAGGCTGAACAGCTTTTTGACAGTTTAGGCAT
GAATATGACAACTGCATTTAATATTTTCATTCGTCAATCATTGAGAATCGGCGGTATACCATTTAAAATTATAAGTGATG
AAAGAGGTTTTTATAATAAATATAATCAAAAAAAACTACATGCTGCTGCTAAACGAATGAATGAAGGGAAATATATAGTG
CATGATATAGTGGAATAG

Structures

Toxin

• AlphaFold DB: M2CK18

Antitoxin

• AlphaFold DB: Q73PY2