Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 635056..635641 Replicon chromosome
Accession NZ_CP051303
Organism Treponema denticola strain OT2B

Toxin (Protein)


Gene name hicA Uniprot ID E9S222
Locus tag E4N91_RS02910 Protein ID WP_002668014.1
Coordinates 635384..635641 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q73KK4
Locus tag E4N91_RS02905 Protein ID WP_002668012.1
Coordinates 635056..635391 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N91_RS02890 (E4N91_02885) 630516..631727 + 1212 WP_002668007.1 substrate-binding domain-containing protein -
E4N91_RS02895 (E4N91_02890) 631838..633331 + 1494 WP_253704355.1 sugar ABC transporter ATP-binding protein -
E4N91_RS02900 (E4N91_02895) 633356..635050 + 1695 WP_253704356.1 galactoside ABC transporter permease -
E4N91_RS02905 (E4N91_02900) 635056..635391 - 336 WP_002668012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4N91_RS02910 (E4N91_02905) 635384..635641 - 258 WP_002668014.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N91_RS02915 (E4N91_02910) 635810..637009 + 1200 WP_253704357.1 galactokinase -
E4N91_RS02920 (E4N91_02915) 637168..637767 + 600 WP_002675657.1 hypothetical protein -
E4N91_RS02925 (E4N91_02920) 637783..639090 + 1308 WP_253704358.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9589.93 Da        Isoelectric Point: 10.6118

>T153978 WP_002668014.1 NZ_CP051303:c635641-635384 [Treponema denticola]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Download         Length: 258 bp

>T153978 NZ_CP067265:641304-642626 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12628.35 Da        Isoelectric Point: 4.9348

>AT153978 WP_002668012.1 NZ_CP051303:c635391-635056 [Treponema denticola]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Download         Length: 336 bp

>AT153978 NZ_CP067265:641038-641304 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9S222

Antitoxin

Source ID Structure
AlphaFold DB Q73KK4

References