Detailed information of TA system TA153977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2513416..2513981
• Replicon: chromosome
• Accession: NZ_CP051302
• Organism: Treponema denticola strain OMZ 853

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HGJ18_RS11780
• Protein ID: WP_253696697.1
• Coordinates: 2513643..2513981 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: M2BA40
• Locus tag: HGJ18_RS11775
• Protein ID: WP_002687528.1
• Coordinates: 2513416..2513649 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGJ18_RS11750 (HGJ18_11825)	2509571..2510593	+	1023	WP_253696694.1	hypothetical protein	-
HGJ18_RS11755 (HGJ18_11830)	2510738..2511019	-	282	WP_253696695.1	flagellar biosynthesis anti-sigma factor FlgM	-
HGJ18_RS11760 (HGJ18_11835)	2511090..2511746	-	657	WP_253698339.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
HGJ18_RS11765 (HGJ18_11840)	2511823..2512233	+	411	WP_002673097.1	hypothetical protein	-
HGJ18_RS11770 (HGJ18_11845)	2512238..2513227	-	990	WP_253696696.1	asparaginase	-
HGJ18_RS11775 (HGJ18_11850)	2513416..2513649	+	234	WP_002687528.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HGJ18_RS11780 (HGJ18_11855)	2513643..2513981	+	339	WP_253696697.1	endoribonuclease MazF	Toxin
HGJ18_RS11785 (HGJ18_11860)	2514021..2515163	+	1143	WP_253696698.1	VWA domain-containing protein	-
HGJ18_RS11790 (HGJ18_11865)	2515268..2517289	+	2022	WP_253696699.1	helicase	-
HGJ18_RS11795 (HGJ18_11870)	2517322..2518086	+	765	WP_253696700.1	prolyl oligopeptidase family serine peptidase	-
HGJ18_RS11800 (HGJ18_11875)	2518097..2518525	+	429	WP_253696701.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• SpoVT-AbrB domain (6-48)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12769.73 Da
• Isoelectric Point: 7.2643

>T153977 WP_253696697.1 NZ_CP051302:2513643-2513981 [Treponema denticola]
MVNSNYVPEKGDLVWLDFDPQTGHEQKGRRPAICVSHKIYNQKTGLALFCPITGHIKGYPFEIVLNKHSINGCILSDQIK
NLDWKQRNCNFIEKALSEEIDSVIANIKLMVE

Nucleotide

• Length: 339 bp

>T153977 NZ_CP067265:308604-308707 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8829.31 Da
• Isoelectric Point: 7.0119

>AT153977 WP_002687528.1 NZ_CP051302:2513416-2513649 [Treponema denticola]
MQMVVQKWGNSLGFRIPSLWAKDNNIKKGSKVEMIIEKEKIVILPQKKSLEDMLALINEDNIHSEISTGYAVGKEEW

Nucleotide

• Length: 234 bp

>AT153977 NZ_CP067265:c308745-308474 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: M2BA40