Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1642596..1643206 Replicon chromosome
Accession NZ_CP051302
Organism Treponema denticola strain OMZ 853

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HGJ18_RS07770 Protein ID WP_253695476.1
Coordinates 1642596..1642889 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HGJ18_RS07775 Protein ID WP_253695478.1
Coordinates 1642892..1643206 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGJ18_RS07750 (HGJ18_07785) 1638569..1639282 - 714 WP_253695468.1 tRNA threonylcarbamoyladenosine dehydratase -
HGJ18_RS07755 (HGJ18_07790) 1639302..1640360 - 1059 WP_253695470.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
HGJ18_RS07760 (HGJ18_07795) 1640422..1641183 + 762 WP_253695472.1 DUF368 domain-containing protein -
HGJ18_RS07765 (HGJ18_07800) 1641294..1642556 + 1263 WP_253695474.1 uracil permease -
HGJ18_RS07770 (HGJ18_07805) 1642596..1642889 + 294 WP_253695476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGJ18_RS07775 (HGJ18_07810) 1642892..1643206 + 315 WP_253695478.1 putative addiction module antidote protein Antitoxin
HGJ18_RS07780 (HGJ18_07815) 1643250..1643912 + 663 WP_253695480.1 C39 family peptidase -
HGJ18_RS07785 (HGJ18_07820) 1643964..1645145 - 1182 WP_253695481.1 YibE/F family protein -
HGJ18_RS07790 (HGJ18_07825) 1645260..1646861 - 1602 WP_253695483.1 5'-nucleotidase C-terminal domain-containing protein -
HGJ18_RS07795 (HGJ18_07830) 1646926..1648176 - 1251 WP_253695484.1 peptidase U32 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11484.58 Da        Isoelectric Point: 10.2475

>T153975 WP_253695476.1 NZ_CP051302:1642596-1642889 [Treponema denticola]
MIEIEKTDIYQKWLENLRDRKAKIIITARIKRLQMGNFGDCKFINKKIYELRINYAKGYRVYFINKNNKIILLLLGGDKS
TQTKDIQKAIDMAEELA

Download         Length: 294 bp

>T153975 NZ_CP067262:15513-15929 [Klebsiella variicola]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGCAGCGGTGCTGAAGCGCCT
TGAGCAGGCGGTGCTGCGCGGTGACCGCATCGTGATCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGCGTGGCGCTGCGCCTCGCAGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11761.73 Da        Isoelectric Point: 8.4123

>AT153975 WP_253695478.1 NZ_CP051302:1642892-1643206 [Treponema denticola]
MKISKWDAADYLKTRKDIAIYLDEILKIAREDNMPELFIEALGDVTRAQGMTDLAKTIDVSRESLYKSLSKKGNPSFSTI
FKVLEFLNLEMSIAAPKTLKQASM

Download         Length: 315 bp

>AT153975 NZ_CP067262:15286-15516 [Klebsiella variicola]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References