Detailed information of TA system TA153972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 418094..418719
• Replicon: chromosome
• Accession: NZ_CP051301
• Organism: Treponema sp. OMZ 799

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4O04_RS01890
• Protein ID: WP_253709427.1
• Coordinates: 418324..418719 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E4O04_RS01885
• Protein ID: WP_253709425.1
• Coordinates: 418094..418324 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O04_RS01870 (E4O04_01860)	413206..414819	+	1614	WP_253709417.1	ATP-binding cassette domain-containing protein	-
E4O04_RS01875 (E4O04_01865)	414852..416903	-	2052	WP_253709420.1	elongation factor G	-
E4O04_RS01880 (E4O04_01870)	416986..417885	-	900	WP_253709422.1	hypothetical protein	-
E4O04_RS01885 (E4O04_01875)	418094..418324	+	231	WP_253709425.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
E4O04_RS01890 (E4O04_01880)	418324..418719	+	396	WP_253709427.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4O04_RS01895 (E4O04_01885)	418843..419730	+	888	WP_253709430.1	fructose bisphosphate aldolase	-
E4O04_RS01900 (E4O04_01890)	419784..422321	-	2538	WP_253709433.1	ribonucleoside-diphosphate reductase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15137.82 Da
• Isoelectric Point: 9.7881

>T153972 WP_253709427.1 NZ_CP051301:418324-418719 [Treponema sp. OMZ 799]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYIEKNKISLIKFLTPFSILNFDDRDAQEFG
KIRTSLKTEGKIICAYDMLIAAQAIAKNLILVTNNTKEFCRIKNLNLEDWK

Nucleotide

• Length: 396 bp

>T153972 NZ_CP067261:c4919338-4919054 [Klebsiella variicola]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGATGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8890.00 Da
• Isoelectric Point: 4.8145

>AT153972 WP_253709425.1 NZ_CP051301:418094-418324 [Treponema sp. OMZ 799]
METAKLFRNGRSQAVRLPKEYNFSGTEVFIRRAGESVILFPKNKDWETFLEGLNGFTDDFMEEGRCQPDLQDRKDL

Nucleotide

• Length: 231 bp

>AT153972 NZ_CP067261:c4919570-4919328 [Klebsiella variicola]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA