Detailed information of TA system TA153971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 2579053..2579605
• Replicon: chromosome
• Accession: NZ_CP051300
• Organism: Treponema sp. OMZ 305

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: ABK01_RS11465
• Protein ID: WP_253675730.1
• Coordinates: 2579303..2579605 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: ABK01_RS11460
• Protein ID: WP_212566621.1
• Coordinates: 2579053..2579322 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABK01_RS11440 (ABK01_11555)	2574132..2574773	-	642	WP_253675728.1	rod-binding protein	-
ABK01_RS11445 (ABK01_11560)	2575181..2575975	-	795	WP_016524140.1	flagellar basal-body rod protein FlgG	-
ABK01_RS11450 (ABK01_11565)	2575990..2576805	-	816	WP_253675729.1	flagellar basal-body rod protein FlgF	-
ABK01_RS11455 (ABK01_11570)	2576896..2578605	-	1710	WP_253676619.1	DEAD/DEAH box helicase	-
ABK01_RS11460 (ABK01_11575)	2579053..2579322	-	270	WP_212566621.1	BrnA antitoxin family protein	Antitoxin
ABK01_RS11465 (ABK01_11580)	2579303..2579605	-	303	WP_253675730.1	BrnT family toxin	Toxin
ABK01_RS11470 (ABK01_11585)	2579807..2580480	+	674	Protein_2245	DUF969 domain-containing protein	-
ABK01_RS11475 (ABK01_11590)	2580473..2581894	+	1422	WP_253675731.1	DUF979 family protein	-
ABK01_RS11480 (ABK01_11600)	2581908..2582543	+	636	WP_253675732.1	PrsW family glutamic-type intramembrane protease	-
ABK01_RS11485 (ABK01_11605)	2582584..2584434	-	1851	WP_253675733.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (8-86)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (30-81)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11616.13 Da
• Isoelectric Point: 5.6438

>T153971 WP_253675730.1 NZ_CP051300:c2579605-2579303 [Treponema sp. OMZ 305]
MDDGLFEWDNKKNTINRQKHGIGFEEALLVFDDPFHIELYDAAHSDKEDRFLAIGTVLNVLVVLVVYTERNQRIRIISAR
PATKKEKGLYYDAVNDTFRS

Nucleotide

• Length: 303 bp

>T153971 NZ_CP067261:4182765-4182983 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10288.93 Da
• Isoelectric Point: 9.5104

>AT153971 WP_212566621.1 NZ_CP051300:c2579322-2579053 [Treponema sp. OMZ 305]
MTLSEAKSMLTQQRIEQLKTLAEQPIDTSDIPELTQEEFFKMYRPIKKPLSIRLDSDIIVWLKSYGKGYQSRINTILRNA
MAAEKQAAQ

Nucleotide

• Length: 270 bp

>AT153971 NZ_CP067261:4182364-4182738 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTCTCGTGTTAG