Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2144952..2145517 Replicon chromosome
Accession NZ_CP051300
Organism Treponema sp. OMZ 305

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ABK01_RS09430 Protein ID WP_212565222.1
Coordinates 2144952..2145290 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ABK01_RS09435 Protein ID WP_212565223.1
Coordinates 2145284..2145517 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABK01_RS09395 (ABK01_09505) 2140076..2140417 + 342 WP_212565215.1 type II toxin-antitoxin system HicB family antitoxin -
ABK01_RS09400 (ABK01_09510) 2140427..2142670 - 2244 WP_253675440.1 DEAD/DEAH box helicase -
ABK01_RS09405 (ABK01_09515) 2142729..2142989 - 261 WP_212565217.1 Txe/YoeB family addiction module toxin -
ABK01_RS09410 (ABK01_09520) 2142986..2143246 - 261 WP_212565218.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ABK01_RS09415 2143288..2143599 + 312 WP_212565219.1 hypothetical protein -
ABK01_RS09420 (ABK01_09530) 2143974..2144465 - 492 WP_253675441.1 hypothetical protein -
ABK01_RS09425 (ABK01_09535) 2144576..2144854 + 279 WP_212565221.1 helix-turn-helix transcriptional regulator -
ABK01_RS09430 (ABK01_09540) 2144952..2145290 - 339 WP_212565222.1 endoribonuclease MazF Toxin
ABK01_RS09435 (ABK01_09545) 2145284..2145517 - 234 WP_212565223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABK01_RS09440 (ABK01_09550) 2145606..2146937 - 1332 WP_253675442.1 ATP-binding protein -
ABK01_RS09445 (ABK01_09555) 2146962..2149874 - 2913 WP_253675443.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12715.64 Da        Isoelectric Point: 6.6261

>T153970 WP_212565222.1 NZ_CP051300:c2145290-2144952 [Treponema sp. OMZ 305]
MVNSNYVPEKGDLVWLDFDPQIGHEQKGRRPAICISHKQYNQKIGLALICPITSHIKGYPFEIVLNGHSISGCILSDQIK
SLDWKQRNCHFIEKAAAEEIDSVVQNIQLMIE

Download         Length: 339 bp

>T153970 NZ_CP067261:c4053618-4053301 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8584.91 Da        Isoelectric Point: 5.7928

>AT153970 WP_212565223.1 NZ_CP051300:c2145517-2145284 [Treponema sp. OMZ 305]
MQAVVQKWGNSLGLRIPSFWAKDNDIKNGSTVEVIMEKEKIIILPQKKSLDAMLALVNEENIHSEISTGYAAGKEAW

Download         Length: 234 bp

>AT153970 NZ_CP067261:c4053308-4053021 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References