Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 4279778..4280694 Replicon chromosome
Accession NZ_CP051298
Organism Alicycliphilus denitrificans strain DP3

Toxin (Protein)


Gene name slvT Uniprot ID A0A858ZXY0
Locus tag HF896_RS20575 Protein ID WP_059401476.1
Coordinates 4279778..4280326 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A858ZYW7
Locus tag HF896_RS20580 Protein ID WP_013520795.1
Coordinates 4280323..4280694 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF896_RS20550 4274810..4276816 + 2007 WP_082136921.1 arsenical pump-driving ATPase -
HF896_RS20555 4277187..4277357 + 171 WP_168727576.1 hypothetical protein -
HF896_RS20560 4277614..4278219 + 606 WP_168728119.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
HF896_RS20565 4278337..4278651 + 315 WP_081462206.1 hypothetical protein -
HF896_RS20570 4278843..4279790 - 948 WP_013520793.1 hypothetical protein -
HF896_RS20575 4279778..4280326 - 549 WP_059401476.1 RES family NAD+ phosphorylase Toxin
HF896_RS20580 4280323..4280694 - 372 WP_013520795.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
HF896_RS20585 4281009..4281338 - 330 WP_013520796.1 chorismate mutase -
HF896_RS20590 4281335..4282834 - 1500 WP_013520797.1 anthranilate synthase component I -
HF896_RS20595 4283176..4284936 + 1761 WP_013723155.1 MCP four helix bundle domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4173379..4302808 129429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(15-168)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20135.98 Da        Isoelectric Point: 4.7789

>T153969 WP_059401476.1 NZ_CP051298:c4280326-4279778 [Alicycliphilus denitrificans]
MIPVAILGEGKAEAFYRIISPAYAGMPLSGMGAARQGGRFNRPSQEALYLAMDEATALAEYKQDNPWLRPGTICTFFVKG
LRVADFSAGFDPQKWPPLWADFAVDWRAEWFGKSVEPPTWYMSEDVIAEGLDGILFPSQARPDGINLVVYRSSARPADQL
RVYDPDGVLPKIAPFAGHPWTP

Download         Length: 549 bp

>T153969 NZ_CP067261:c2742692-2741370 [Klebsiella variicola]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGCACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATTACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTACCCGACAGCCCGCAGGTCCGCGATCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTGGGACGGGATAGCGTAGGGGCGGTGACTCTGCTACCGCCGGG
AGAAGAGGCGCACCTCGAGGGGTTGCGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCCTACCAGT
CGGATATCCCTCTCGGGATGATTACCGGCCAGGATGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGTGGGCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCTAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGGGAACTGG
GCCTGGCGGTGCCGGAGGCAGAGATTATCACCACGCCACGGATCCGCGCGCTGGCGGTGACCCGCTTTGACCGGCGCTGG
GCGCAGGAGGGACGGGTACTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGCATACCGTCGTCGATGAAATA
TGAATCTGACGGCGGGCCGGGTATTGCGGCAATCATGGCCTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGATCGCGCAG
ACTTTATGAAATTCATGGTTTTTCAGTGGCTGGTTGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGTGGCAGCTACCGTCTAACGCCGTTCTACGACATCATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCAACCGCCAAAGCGGTGAACTTTCCTGGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCGGGCCATTACGGAAAATATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13512.43 Da        Isoelectric Point: 5.7134

>AT153969 WP_013520795.1 NZ_CP051298:c4280694-4280323 [Alicycliphilus denitrificans]
MSAVLQQPFVEQFREPGTPYLSPVLLGDFLGFQVQELAERAHVHRNTPTARPQAPQLQKYLQDMVRVLAVATEMTGDEKR
AAFLVRNEPLRAFGYKTADALVQEGRVDAVIAYLESLAGGAAG

Download         Length: 372 bp

>AT153969 NZ_CP067261:c2742958-2742692 [Klebsiella variicola]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCGACACTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTAGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A858ZXY0

Antitoxin

Source ID Structure
AlphaFold DB A0A858ZYW7

References