Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1333708..1335325 | Replicon | plasmid megaplasmid |
| Accession | NZ_CP051295 | ||
| Organism | Ralstonia solanacearum strain CIAT_078 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | F6GA13 |
| Locus tag | G8D25_RS05365 | Protein ID | WP_014619008.1 |
| Coordinates | 1333979..1335325 (+) | Length | 449 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | G8D25_RS05360 | Protein ID | WP_042549221.1 |
| Coordinates | 1333708..1333974 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G8D25_RS05330 (G8D25_05335) | 1328933..1329409 | + | 477 | WP_003265832.1 | RidA family protein | - |
| G8D25_RS05335 (G8D25_05340) | 1329512..1330348 | + | 837 | WP_014619014.1 | AraC family transcriptional regulator | - |
| G8D25_RS05340 (G8D25_05345) | 1330351..1331469 | + | 1119 | WP_014619013.1 | dienelactone hydrolase | - |
| G8D25_RS05345 (G8D25_05350) | 1331508..1331891 | - | 384 | WP_014619012.1 | VOC family protein | - |
| G8D25_RS05350 (G8D25_05355) | 1332148..1332582 | + | 435 | WP_042549879.1 | PGDYG domain-containing protein | - |
| G8D25_RS05355 (G8D25_05360) | 1332598..1333449 | - | 852 | WP_124994750.1 | hypothetical protein | - |
| G8D25_RS05360 (G8D25_05365) | 1333708..1333974 | + | 267 | WP_042549221.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| G8D25_RS05365 (G8D25_05370) | 1333979..1335325 | + | 1347 | WP_014619008.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| G8D25_RS05370 (G8D25_05375) | 1335420..1336316 | + | 897 | WP_014619007.1 | oxygenase MpaB family protein | - |
| G8D25_RS05375 (G8D25_05380) | 1336320..1337891 | - | 1572 | WP_014619006.1 | MDR family MFS transporter | - |
| G8D25_RS05380 (G8D25_05385) | 1337984..1338934 | - | 951 | WP_039552434.1 | LysR family transcriptional regulator | - |
| G8D25_RS05385 (G8D25_05390) | 1339073..1339699 | + | 627 | WP_014619003.1 | FMN-dependent NADH-azoreductase | - |
| G8D25_RS05390 (G8D25_05395) | 1339846..1339992 | - | 147 | WP_014619002.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | cheY / flgG / fliM / fliI / acrB / tsr / adeG / cheY / cheB / cheW / motA / tsr / cyaB | 1..1907373 | 1907373 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 449 a.a. Molecular weight: 49543.83 Da Isoelectric Point: 7.8550
>T153965 WP_014619008.1 NZ_CP051295:1333979-1335325 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDSHFRIS
IAGAQEKTAFLQIDGHWYRPRGATPTSHIFKLPMGLVGNMKLDLSDSVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLLRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGIVTSDGAD
AASIVDNLVARTPEVARTVRALLPEGFPQPLADRILQGLRHAADKLAG
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDSHFRIS
IAGAQEKTAFLQIDGHWYRPRGATPTSHIFKLPMGLVGNMKLDLSDSVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLLRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGIVTSDGAD
AASIVDNLVARTPEVARTVRALLPEGFPQPLADRILQGLRHAADKLAG
Download Length: 1347 bp
>T153965 NZ_CP067261:352766-353113 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9636.14 Da Isoelectric Point: 10.9487
>AT153965 WP_042549221.1 NZ_CP051295:1333708-1333974 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGVRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDAAGEPGR
PASDQPQW
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGVRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDAAGEPGR
PASDQPQW
Download Length: 267 bp
>AT153965 NZ_CP067261:353113-353412 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|