Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/DUF1778(antitoxin)
Location 3265366..3266132 Replicon chromosome
Accession NZ_CP051293
Organism Mesorhizobium sp. NZP2077

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HGP13_RS16230 Protein ID WP_172234742.1
Coordinates 3265647..3266132 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HGP13_RS16225 Protein ID WP_172227191.1
Coordinates 3265366..3265647 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGP13_RS16200 3260593..3261579 + 987 WP_172234740.1 ABC transporter permease -
HGP13_RS16205 3261582..3262130 + 549 WP_172227185.1 gluconokinase -
HGP13_RS16210 3262125..3263261 - 1137 WP_172227187.1 hypothetical protein -
HGP13_RS16215 3263439..3263888 - 450 WP_172234741.1 Rrf2 family transcriptional regulator -
HGP13_RS16220 3264138..3265124 - 987 WP_172227189.1 sulfate ABC transporter substrate-binding protein -
HGP13_RS16225 3265366..3265647 + 282 WP_172227191.1 DUF1778 domain-containing protein Antitoxin
HGP13_RS16230 3265647..3266132 + 486 WP_172234742.1 GNAT family N-acetyltransferase Toxin
HGP13_RS16235 3266186..3267226 - 1041 WP_172227193.1 sulfate/molybdate ABC transporter ATP-binding protein -
HGP13_RS16240 3267240..3268124 - 885 WP_172227196.1 sulfate ABC transporter permease subunit CysW -
HGP13_RS16245 3268117..3268968 - 852 WP_172227198.1 sulfate ABC transporter permease subunit CysT -
HGP13_RS16250 3268991..3270019 - 1029 WP_172227200.1 sulfate ABC transporter substrate-binding protein -
HGP13_RS16255 3270310..3271041 - 732 WP_172227202.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(2-76)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17035.62 Da        Isoelectric Point: 10.0226

>T153963 WP_172234742.1 NZ_CP051293:3265647-3266132 [Mesorhizobium sp. NZP2077]
MLSAPTPLAENHDLELFQSGTESLDQWLRRRARANQVGGASRTYVVAEGARVVGYYCLSSGGLDLTSAPGPIRRNIPDPI
PIVVLGRLAVDAGWQGKGLGAALLQDAVLRAGHAATILGIRGIFVHAVSDEAKAFYQRYGFAASPKNPMTLVLSLKGLVK
G

Download         Length: 486 bp

>T153963 NZ_CP067257:c35734-35318 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10620.15 Da        Isoelectric Point: 7.2028

>AT153963 WP_172227191.1 NZ_CP051293:3265366-3265647 [Mesorhizobium sp. NZP2077]
MTKAAPETHAKPVNLRIREDMRILIDRAAKLRGKTRSDFMIDAAYRAAEDTLLNQALIKVDPESYRHYLDILDEPPGGEG
FGRLMNAPRPWQD

Download         Length: 282 bp

>AT153963 NZ_CP067257:c35961-35731 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References