Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 962415..962988 Replicon chromosome
Accession NZ_CP051292
Organism Helicobacter pylori strain ASHA-003

Toxin (Protein)


Gene name relE Uniprot ID Q9ZKV4
Locus tag HGI45_RS04440 Protein ID WP_001880357.1
Coordinates 962415..962687 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M3K213
Locus tag HGI45_RS04445 Protein ID WP_001134114.1
Coordinates 962701..962988 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI45_RS04400 957887..958366 + 480 WP_202136624.1 hypothetical protein -
HGI45_RS04405 958363..958653 + 291 WP_000736104.1 TrbC/VirB2 family protein -
HGI45_RS04410 958663..958926 + 264 WP_001177721.1 hypothetical protein -
HGI45_RS04415 958938..959174 + 237 WP_202136625.1 hypothetical protein -
HGI45_RS04420 959174..960046 + 873 Protein_866 transporter -
HGI45_RS04425 960075..961352 - 1278 WP_001274352.1 transposase -
HGI45_RS04430 961327..961980 - 654 WP_001042556.1 IS607 family transposase -
HGI45_RS04435 962116..962367 - 252 WP_079354583.1 hypothetical protein -
HGI45_RS04440 962415..962687 - 273 WP_001880357.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
HGI45_RS04445 962701..962988 - 288 WP_001134114.1 type II toxin-antitoxin system antitoxin Antitoxin
HGI45_RS04450 963560..965803 - 2244 WP_202136633.1 outer membrane beta-barrel protein -
HGI45_RS04465 966134..966781 + 648 Protein_873 hypothetical protein -
HGI45_RS04470 966732..967844 - 1113 WP_202136642.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.42 Da        Isoelectric Point: 9.7463

>T153961 WP_001880357.1 NZ_CP051292:c962687-962415 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T153961 NZ_CP067255:c5276353-5275970 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11378.18 Da        Isoelectric Point: 10.4152

>AT153961 WP_001134114.1 NZ_CP051292:c962988-962701 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNFLNSIKAKQKRALEKLKEIQTQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Download         Length: 288 bp

>AT153961 NZ_CP067255:c5276595-5276353 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0VLH9

Antitoxin

Source ID Structure
AlphaFold DB M3K213

References