Detailed information of TA system TA153960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 962116..962687
• Replicon: chromosome
• Accession: NZ_CP051292
• Organism: Helicobacter pylori strain ASHA-003

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9ZKV4
• Locus tag: HGI45_RS04440
• Protein ID: WP_001880357.1
• Coordinates: 962415..962687 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HGI45_RS04435
• Protein ID: WP_079354583.1
• Coordinates: 962116..962367 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI45_RS04400	957887..958366	+	480	WP_202136624.1	hypothetical protein	-
HGI45_RS04405	958363..958653	+	291	WP_000736104.1	TrbC/VirB2 family protein	-
HGI45_RS04410	958663..958926	+	264	WP_001177721.1	hypothetical protein	-
HGI45_RS04415	958938..959174	+	237	WP_202136625.1	hypothetical protein	-
HGI45_RS04420	959174..960046	+	873	Protein_866	transporter	-
HGI45_RS04425	960075..961352	-	1278	WP_001274352.1	transposase	-
HGI45_RS04430	961327..961980	-	654	WP_001042556.1	IS607 family transposase	-
HGI45_RS04435	962116..962367	-	252	WP_079354583.1	hypothetical protein	Antitoxin
HGI45_RS04440	962415..962687	-	273	WP_001880357.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
HGI45_RS04445	962701..962988	-	288	WP_001134114.1	type II toxin-antitoxin system antitoxin	-
HGI45_RS04450	963560..965803	-	2244	WP_202136633.1	outer membrane beta-barrel protein	-
HGI45_RS04465	966134..966781	+	648	Protein_873	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10484.42 Da
• Isoelectric Point: 9.7463

>T153960 WP_001880357.1 NZ_CP051292:c962687-962415 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T153960 NZ_CP067255:c4952917-4952000 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9632.75 Da
• Isoelectric Point: 4.6258

>AT153960 WP_079354583.1 NZ_CP051292:c962367-962116 [Helicobacter pylori]
MPNTTKKDYTKYSQRQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAMREALNGENLEVIEDFSAWANEIKKEVN
AEN

Nucleotide

• Length: 252 bp

>AT153960 NZ_CP067255:c4953681-4952923 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A1W0VLH9