Detailed information of TA system TA153947

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4350663..4351495
• Replicon: chromosome
• Accession: NZ_CP051263
• Organism: Escherichia coli CFT073

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0H2VCF5
• Locus tag: HGG68_RS20940
• Protein ID: WP_000854681.1
• Coordinates: 4351118..4351495 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A3Z9KHH3
• Locus tag: HGG68_RS20935
• Protein ID: WP_021562928.1
• Coordinates: 4350663..4351028 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGG68_RS20900	4346580..4347260	+	681	WP_001278650.1	WYL domain-containing protein	-
HGG68_RS20905	4347408..4348085	+	678	WP_001097301.1	hypothetical protein	-
HGG68_RS20910	4348091..4348324	+	234	WP_001278287.1	DUF905 family protein	-
HGG68_RS20915	4348414..4349232	+	819	WP_001175163.1	DUF945 domain-containing protein	-
HGG68_RS20920	4349324..4349809	+	486	WP_000206666.1	antirestriction protein	-
HGG68_RS20925	4349824..4350300	+	477	WP_001186171.1	RadC family protein	-
HGG68_RS20930	4350363..4350584	+	222	WP_000692300.1	DUF987 domain-containing protein	-
HGG68_RS20935	4350663..4351028	+	366	WP_021562928.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HGG68_RS20940	4351118..4351495	+	378	WP_000854681.1	TA system toxin CbtA family protein	Toxin
HGG68_RS20945	4351492..4351641	+	150	Protein_4106	hypothetical protein	-
HGG68_RS20950	4351717..4351914	+	198	WP_023563519.1	DUF957 domain-containing protein	-
HGG68_RS20955	4351999..4352841	+	843	WP_001280503.1	DUF4942 domain-containing protein	-
HGG68_RS20960	4353437..4353934	+	498	WP_000509808.1	hypothetical protein	-
HGG68_RS20965	4354101..4355024	+	924	WP_001351210.1	carboxylate/amino acid/amine transporter	-
HGG68_RS20970	4355028..4355846	-	819	WP_000779409.1	lipoprotein NlpA	-
HGG68_RS20975	4356068..4356361	+	294	WP_001297978.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (17-116)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13963.89 Da
• Isoelectric Point: 7.4348

>T153947 WP_000854681.1 NZ_CP051263:4351118-4351495 [Escherichia coli CFT073]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T153947 NZ_CP067251:111170-111586 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13528.32 Da
• Isoelectric Point: 6.4648

>AT153947 WP_021562928.1 NZ_CP051263:4350663-4351028 [Escherichia coli CFT073]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 366 bp

>AT153947 NZ_CP067251:110943-111173 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0H2VCF5

Antitoxin

• AlphaFold DB: A0A3Z9KHH3