Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3517670..3518504 Replicon chromosome
Accession NZ_CP051263
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag HGG68_RS16920 Protein ID WP_000854688.1
Coordinates 3518127..3518504 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag HGG68_RS16915 Protein ID WP_001285596.1
Coordinates 3517670..3518050 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGG68_RS16880 3513955..3514410 + 456 WP_000581502.1 hypothetical protein -
HGG68_RS16885 3514489..3514722 + 234 WP_001119727.1 DUF905 family protein -
HGG68_RS16890 3514823..3515641 + 819 WP_001234616.1 DUF945 domain-containing protein -
HGG68_RS16895 3515696..3516181 + 486 WP_000849564.1 antirestriction protein -
HGG68_RS16900 3516197..3516673 + 477 WP_001186726.1 RadC family protein -
HGG68_RS16905 3516736..3516957 + 222 WP_000692329.1 DUF987 domain-containing protein -
HGG68_RS16910 3516976..3517620 + 645 WP_000094917.1 hypothetical protein -
HGG68_RS16915 3517670..3518050 + 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HGG68_RS16920 3518127..3518504 + 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
HGG68_RS16925 3518501..3518989 + 489 WP_000761701.1 hypothetical protein -
HGG68_RS16930 3519006..3519203 + 198 WP_000839260.1 DUF957 domain-containing protein -
HGG68_RS16935 3519288..3520133 + 846 WP_001280441.1 DUF4942 domain-containing protein -
HGG68_RS16940 3520202..3520597 + 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
HGG68_RS16945 3520590..3521524 + 935 Protein_3319 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HGG68_RS16950 3521956..3522111 + 156 WP_000729639.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM 3516197..3541832 25635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T153945 WP_000854688.1 NZ_CP051263:3518127-3518504 [Escherichia coli CFT073]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T153945 NZ_CP067251:c51896-51747 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT153945 WP_001285596.1 NZ_CP051263:3517670-3518050 [Escherichia coli CFT073]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT153945 NZ_CP067251:51940-52001 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References