Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2377350..2378181 Replicon chromosome
Accession NZ_CP051263
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HGG68_RS11595 Protein ID WP_000854814.1
Coordinates 2377807..2378181 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HGG68_RS11590 Protein ID WP_001285586.1
Coordinates 2377350..2377718 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGG68_RS11555 2372567..2373637 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
HGG68_RS11560 2373773..2374450 + 678 WP_001362823.1 hypothetical protein -
HGG68_RS11565 2374466..2374876 + 411 WP_000846704.1 hypothetical protein -
HGG68_RS11570 2375097..2375918 + 822 WP_001234569.1 DUF945 domain-containing protein -
HGG68_RS11575 2376009..2376494 + 486 WP_000213703.1 antirestriction protein -
HGG68_RS11580 2376510..2376986 + 477 WP_001351157.1 RadC family protein -
HGG68_RS11585 2377055..2377276 + 222 WP_000692323.1 DUF987 domain-containing protein -
HGG68_RS11590 2377350..2377718 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HGG68_RS11595 2377807..2378181 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HGG68_RS11600 2378178..2378372 + 195 WP_000988601.1 hypothetical protein -
HGG68_RS11605 2378385..2378498 + 114 WP_001161660.1 DUF957 domain-containing protein -
HGG68_RS11610 2378787..2378960 - 174 WP_032082634.1 transposase domain-containing protein -
HGG68_RS11615 2378987..2379169 + 183 WP_001016348.1 hypothetical protein -
HGG68_RS11620 2379270..2379599 - 330 WP_000450409.1 DUF496 family protein -
HGG68_RS11625 2379771..2380829 - 1059 WP_001200890.1 FUSC family protein -
HGG68_RS11630 2381027..2381500 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HGG68_RS11635 2381619..2382785 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T153941 WP_000854814.1 NZ_CP051263:2377807-2378181 [Escherichia coli CFT073]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T153941 NZ_CP067250:c3759243-3758836 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT153941 WP_001285586.1 NZ_CP051263:2377350-2377718 [Escherichia coli CFT073]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT153941 NZ_CP067250:c3759490-3759224 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References