Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 557657..558275 Replicon chromosome
Accession NZ_CP051263
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HGG68_RS02570 Protein ID WP_001291435.1
Coordinates 557657..557875 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HGG68_RS02575 Protein ID WP_000344800.1
Coordinates 557901..558275 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGG68_RS02535 552945..553517 + 573 WP_000779831.1 YbaY family lipoprotein -
HGG68_RS02540 553548..553859 - 312 WP_000409908.1 MGMT family protein -
HGG68_RS02550 554238..554591 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HGG68_RS02555 554633..556183 - 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HGG68_RS02560 556347..556817 - 471 WP_001304825.1 YlaC family protein -
HGG68_RS02565 556933..557484 - 552 WP_000102539.1 maltose O-acetyltransferase -
HGG68_RS02570 557657..557875 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HGG68_RS02575 557901..558275 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HGG68_RS02580 558820..561969 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HGG68_RS02585 561992..563185 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153930 WP_001291435.1 NZ_CP051263:c557875-557657 [Escherichia coli CFT073]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153930 NZ_CP067250:921004-921402 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT153930 WP_000344800.1 NZ_CP051263:c558275-557901 [Escherichia coli CFT073]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT153930 NZ_CP067250:920708-921001 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References