Detailed information of TA system TA153925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): EcnAB/-
• Location: 4828709..4829094
• Replicon: chromosome
• Accession: NZ_CP051261
• Organism: Xanthomonas sp. SI

Toxin (Protein)

• Gene name: EcnB
• Uniprot ID: A0A0K2ZHE5
• Locus tag: HEP75_RS20580
• Protein ID: WP_003469322.1
• Coordinates: 4828709..4828843 (-)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: EcnA
• Uniprot ID: -
• Locus tag: HEP75_RS20585
• Protein ID: WP_185814371.1
• Coordinates: 4828942..4829094 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEP75_RS20560	4824773..4825696	-	924	WP_185824756.1	MBL fold metallo-hydrolase	-
HEP75_RS20565	4825976..4827268	-	1293	WP_185824757.1	tryptophan--tRNA ligase	-
HEP75_RS20570	4827379..4828218	+	840	WP_185824758.1	hypothetical protein	-
HEP75_RS20575	4828293..4828508	-	216	WP_145703764.1	CsbD family protein	-
HEP75_RS20580	4828709..4828843	-	135	WP_003469322.1	entericidin A/B family lipoprotein	Toxin
HEP75_RS20585	4828942..4829094	-	153	WP_185814371.1	entericidin A/B family lipoprotein	Antitoxin
HEP75_RS20590	4829238..4830161	-	924	WP_185821402.1	arginase	-
HEP75_RS20600	4830579..4831427	-	849	WP_185824759.1	SPOR domain-containing protein	-
HEP75_RS20605	4831437..4832177	-	741	WP_185814374.1	type III pantothenate kinase	-
HEP75_RS20610	4832174..4833169	-	996	WP_185814375.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-
HEP75_RS20615	4833306..4833578	+	273	WP_185821406.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-39)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4604.40 Da
• Isoelectric Point: 9.2977

>T153925 WP_003469322.1 NZ_CP051261:c4828843-4828709 [Xanthomonas sp. SI]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Nucleotide

• Length: 135 bp

>T153925 NZ_CP067250:289512-289685 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5305.33 Da
• Isoelectric Point: 7.5953

>AT153925 WP_185814371.1 NZ_CP051261:c4829094-4828942 [Xanthomonas sp. SI]
MKRLLTLMMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVETKADDCSDGKC

Nucleotide

• Length: 153 bp

>AT153925 NZ_CP067250:289188-289484 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0K2ZHE5