Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 51978..52500 | Replicon | plasmid pSCZE4 |
| Accession | NZ_CP051226 | ||
| Organism | Escherichia coli strain SCZE5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | HF562_RS24765 | Protein ID | WP_000638823.1 |
| Coordinates | 51978..52259 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | HF562_RS24770 | Protein ID | WP_000121741.1 |
| Coordinates | 52249..52500 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF562_RS24730 | 48127..48447 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| HF562_RS24735 | 48518..48706 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| HF562_RS24740 | 48808..49392 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| HF562_RS24745 | 49413..49811 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| HF562_RS24750 | 49930..50367 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| HF562_RS24755 | 50373..51608 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| HF562_RS24760 | 51611..51910 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| HF562_RS24765 | 51978..52259 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HF562_RS24770 | 52249..52500 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| HF562_RS24775 | 52600..53235 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| HF562_RS24780 | 53308..53595 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| HF562_RS24785 | 53608..53862 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| HF562_RS24790 | 53864..54505 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| HF562_RS24795 | 54511..55506 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| HF562_RS24800 | 55510..55767 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| HF562_RS24805 | 55764..56066 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| HF562_RS24810 | 56047..56304 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| HF562_RS24815 | 56337..56783 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| HF562_RS24820 | 56794..56964 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| HF562_RS24825 | 56968..57411 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60732 | 60732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T153914 WP_000638823.1 NZ_CP051226:c52259-51978 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T153914 NZ_CP067245:2022949-2023227 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT153914 WP_000121741.1 NZ_CP051226:c52500-52249 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT153914 NZ_CP067245:2022686-2022946 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|